Abstract
Purpose: In a prospective study, conventional IVF and intracytoplasmic sperm injection (ICSI) were performed on sibling oocytes of 22 patients with unexplained infertility (Group A) and 24 patients with borderline semen (Group B).
Results: In Group A, there was no significant difference (P=0.070) in the fertilization rate per oocyte between ICSI (63%) and conventional IVF (50.7%), however, there was total failure of fertilization in conventional IVF in 5 of the 22 patients with IVF and none in ICSI. In group B, there was a significant difference (P<0.001) between the fertilization rate per oocyte in ICSI (59%) and conventional IVF (27.1%). There was total failure of fertilization in 11 patients after conventional IVF and none after ICSI.
Conclusions: The study showed that 22.7% of unexplained infertility and 45.8% of patients with borderline semen would have lost their chance of embryo transfer completely because of total failure of fertilization if ICSI was not performed on some oocytes in this cycle.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Navot D, Muasher SJ, Oehninger S, Liu H-C, Veeck LL, Kreiner D, Rosenwaks Z: The value of in vitro fertilization for the treatment of unexplained infertility. Fertil Steril 1988;49:854–857
Payne D, Flaherty SP, Jeffrey R, Warners GM, Matthews CD: Successful treatment of severe male factor infertility in 100 consecutive cycles using intracytoplasmic sperm injection. Hum Reprod 1994;9:2051–2057
Van Steirteghem AC, Nagy Z, Joris H, Liu J, Staessen C, Smitz J, Wisanto A, Devroey P: High fertilization and implantation rates after intracytoplasmic sperm injection. Hum Reprod 1993;8:1061–1066
World Health Organization: WHO Laboratory Manual for the Examination of Human Semen and Sperm Cervical Mucus Interaction, 3rd ed. Cambridge, Cambridge University Press, 1992
Aboulghar MA, Mansour RT, Serour GI, Amin YM: The prognostic value of successful in vitro fertilization in subsequent trials. Hum Reprod 1994;9:1932–1934
Lucena E, Lucena C, Gomez M, Ortiz JA, Ruiz J, Aango A, Diaz C, Benerman C: Recovery of motile sperm using the migration-sedimentation technique in an in vitro fertilization-embryo transfer. Hum Reprod 1989;4:163–165
Mansour RT, Aboulghar MA, Serour GI: In vitro Fertilization and Embryo transfer: Report of the Egyptian IVF-ET Center. J Egypt Soc Obstet Gynecol 1988;XIV:18–28
Aboulghar MA, Mansour RT, Serour GI, Amin Y, Abbas AM, Salah IM: Ovarian superstimulation and intrauterine insemination for the treatment of unexplained infertility. Fertil Steril 1993;60:303–306
Asch RH, Balmaceda JP, Ellsworth LR, Wong PC: Preliminary experience with gamete intrafallopian transfer (GIFT). Fertil Steril 1986;45:366
Audibert F, Hedon B, Arnal F, Humeau C, Badoc E, Virenque V, Boulot P, Mares P, Laffargue F, Viala JL: Results of IVF attempts in patients with unexplained infertility. Hum Reprod 1989;4:766–771
Kahn JA, Sunde A, During V, Sordal T, Molne K: Treatment of unexplained infertility. Fallopian tube sperm perfusion (FSP). Acta Obstet Gynecol Scand 1993;72:193–199
Atiken J, Best F, Richardson DW, Djahanbakhch O, Mortimer D, Templeton A, Less M: An analysis of sperm function in cases of unexplained infertility: Conventional criteria movement characteristics and fertilization capacity. Fertil Steril 1982;38:212–221
Clark RV, Sherins RJ: Use of semen analysis in the evaluation of the infertile couple.In Santen RJ, Swerdloff RS (eds), Male Reproductive Dysfunction. New York, Marcel Dekker, 1986, p 253
Overstreet JW, Davis RO, Katz DF: Semen evaluation.In Infertility and Reproductive Medicine, Clinics of North America, Overstreet JW (ed). Philadelphia, W.B. Saunders, 1992, p 329
Barfield A, Melo J, Coutinho E,et al. Pregnancies associated with sperm concentrations below 10 million/mL in clinical studies of a potential male contraceptive method, monthly depot medroxyprogesterone acetate and testosterone esters. Contraception 1979;20:121
Morales P, Katz DF, Overstreet JW,et al. The relationship between the motility and morphology of spermatozoa in semen. J Androl 1988;9:241
Palermo G, Joris H, Derde MP, Camus M, Devroey P, Steirteghem A: Sperm characteristics and outcome of human assisted fertilization by subzonal insemination and intracytoplasmic sperm injection. Fertil Steril 1993;59:826–835
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Aboulghar, M.A., Mansour, R.T., Serour, G.I. et al. Intracytoplasmic sperm injection and conventional in vitro fertilization for sibling oocytes in cases of unexplained infertility and borderline semen. J Assist Reprod Genet 13, 38–42 (1996). https://doi.org/10.1007/BF02068867
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02068867