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Effect of metabolic inhibitors on lauric acid-induced hemolysis

  • Models in Toxicology
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Abstract

Lauric acid reduced osmotic RBC fragility at low salt concentrations and caused hemolysis under normotonic conditions. KCN inhibited the hemolytic effect of l.a. under normotonic but did not influence its action under hypotonic conditions. It is concluded that l.a.-induced hemolysis requires penetration of the f.a. into a deep membrane pool whereas binding of l.a. in the superficial RBC-membrane pool is sufficient to reduce osmotic fragility of RBC at low salt concentrations.

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Authors and Affiliations

  1. Laboratory of Experimental and Toxicological Pathology, Institute of Pathological Anatomy, University of Zurich, CH-8006, Zürich, Switzerland

    Elisabeth Bachmann & Gerhard Zbinden

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  1. Elisabeth Bachmann
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  2. Gerhard Zbinden
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Bachmann, E., Zbinden, G. Effect of metabolic inhibitors on lauric acid-induced hemolysis. Agents and Actions 3, 45–47 (1973). https://doi.org/10.1007/BF02023851

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  • DOI: https://doi.org/10.1007/BF02023851

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