It is well known that Down syndrome (DS) affects multiple organ systems, including cardiovascular, gastrointestinal, hematological, and musculoskeletal. Involvement of the lungs by a characteristic form of subpleural cystic disease is well described in the pathology literature. The imaging characteristics of changes caused by this disease have not been previously described in detail in the radiology literature, possibly because they are not well appreciated on plain chest radiographs. We present a child with DS in whom extensive cystic lung disease was discovered incidentally at CT, and review the current literature regarding the pathogenesis of cystic pulmonary abnormalities in children with DS.
KeywordsPublic Health Lung Disease Organ System Current Literature Imaging Characteristic
- 1.Nelson W (1983) Textbook of pediatrics. Saunders, Philadelphia, pp 295–299Google Scholar
- 2.Taybi H (1990) Radiology of syndromes, metabolic disorders, and skeletal dysplasias. Year Book, Chicago, p 94Google Scholar
- 3.Smith DW (1982) Recognizable patterns of human malformation, 3rd edn. Saunders, Philadelphia, pp 6–8Google Scholar
- 4.Stein SM, Kirchner SG, Hernanz-Schulman M (1981) Atlantooccipital subluxation in Down syndrome. Pediatr Radiol 21: 121–124Google Scholar