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Pediatric Radiology

, Volume 24, Issue 2, pp 122–127 | Cite as

MRI assessment of myelination: an age standardization

  • M. Staudt
  • C. Schropp
  • F. Staudt
  • N. Obletter
  • K. Bise
  • A. Breit
  • H. M. Weinmann
Originals

Abstract

777 cerebral MRI examinations of children aged 3 days to 14 years were staged for myelination to establish an age standardization. Staging was performed using a system proposed in a previous paper [1], separately ranking 10 different regions of the brain. Interpretation of the results led to the identification of four clinical diagnoses that are frequently associated with delays in myelination: West syndrome, cerebral palsy, developmental retardation, and congenital anomalies. In addition, it was found that assessment of myelination in children with head injuries was not practical as alterations in MRI signal can simulate earlier stages of myelination. Age limits were therefore calculated from the case material after excluding all children with these conditions. When simplifications of the definition of the stages are applied, these age limits for the various stages of myelination of each of the 10 regions of the brain make the staging system applicable for routine assessment of myelination.

Keywords

Public Health Congenital Anomaly Clinical Diagnosis Cerebral Palsy Head Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • M. Staudt
    • 1
  • C. Schropp
    • 1
  • F. Staudt
    • 1
  • N. Obletter
    • 2
  • K. Bise
    • 3
  • A. Breit
    • 4
  • H. M. Weinmann
    • 5
  1. 1.Kinderklinik Dritter OrdenPassauGermany
  2. 2.Radiologische Praxis im KlinikumIngolstadtGermany
  3. 3.Neuropathologisches Institut der Ludwig-Maximilians-UniversitätMunichGermany
  4. 4.MR Tomographie am KlinikumPassauGermany
  5. 5.Kinderklinik SchwabingMunichGermany

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