Abstract
The local cerebral vascular response to hyperventilation vas investigated in five distressed, intubated infants by means of a T2* sensitive gradient-echo MRI technique at 1.5 T. In one preterm infant, the MR signal change during hyperventilation was sparse. In four term infants, the mean MR signal of the brain slice investigated decreased by 1.2–2.6% per kPa change inPCO2 as a reflection of decreased cerebral blood flow during hyperventilation. Pixel-wise analysis revealed absence of vascular response in the basal ganglia, the thalamus or in the occipital region. In two adult controls, who hyperventilated voluntarily, the vascular reactivity was homogeneously distributed predominantly over the grey matter. The experiments demonstrate that local impairment of vascular CO2 reactivity in the distressed infant brain can be detected by T2* sensitive gradient-echo MRI, which is also known as functional MRI.
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Pryds O, Greisen G, Lou H, Friis Hansen B (1990) Vasoparalysis associated with brain damage in asphyxiated term infants. J Pediatr 117: 119–125
Haxby JV, Grady CL, Ungerleider LG, Horwitz B (1991) Mapping the functional neuroanatomy of the intact human brain with brain work imaging. Neuropsychologia 29: 539–555
Tikofsky RS, Hellman RS (1991) Brain single photon emission computed tomography: newer activation and intervention studies. Semin Nucl Med 21: 40–57
Ashwal S, Stringer W, Tomasi L, Schneider S, Thompson J, Perkin R (1990) Cerebral blood flow and carbon dioxide reactivity in children with bacterial meningitis. J Pediatr 117: 523–530
Ogawa S, Lee TM, Kay AR, Tank DW (1990) Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA 87: 9868–9872
Belliveau JW, Kennedy DN, McKinstry RC, Buchbinder BR, Weisskoff RM, Cohen MS, Vevea JM, Brady TJ, Rosen BR (1991) Functional mapping of the human visual cortex by magnetic resonance imaging. Science 254: 716–719
Frahm J, Bruhn H, Merboldt KD, Hanicke W (1992) Dynamic MR imaging of human brain oxygenation during rest and photic stimulation. J magn Reson Imaging 2: 501–505
Henriksen O, Larsson HBW, Ring P, Rostrup E, Stensgaard A, Stubgaard M, Ståhlberg F, Söndergaard L, Thomsen C, Toft P (1993) Functional MR imaging at 1.5 T. Initial results using photic and motoric stimulation. Acta Radiol 34: 101–103
Rostrup E, Larsson HBW, Toft PB, Garde K, Thomsen C, Ring P, Söndergaard L, Henriksen O (1994) Functional MRI of CO2 induced increase in cerebral perfusion. NMR Biomed 7: 29–34
Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hanicke W, Sauter R (1989) Localized high-resolution proton NMR spectroscopy using stimulated echoes: initial applications to human brain in vivo. Magn Reson Med 9: 79–93
Toft PB, Leth H, Pryds O, Peitersen B, Lou HC, Henriksen O (1994) Periventricular lactate accumulation in prematurity: accentuation in intrauterine growth retardation. In: Lou HC, Greisen G, Falck Larsen J (eds) Brain lesion in the newborn. (37th Alfred Benzon symposium). Munksgaard, Copenhagen, pp 302–313
Duyn JH, Moonen CTW, de Boer RW, van Yperen GH, Luyten PR (1993) Inflow versus deoxyhemoglobin effects in “BOLD” functional MRI using gradient echoes at 1.5T. (abstract) Proceedings of Society of Magnetic Resonance in Medicine, Berkeley, Calif, p 168
Pryds O, Greisen G, Skov LL, Friis-Hansen B (1990) Carbon dioxide-related changes in cerebral blood volume and cerebral blood flow in mechanically ventilated preterm neonates: comparison of near infrared spectrophotometry and133Xenon clearance. Pediatr Res 27: 445–449
Hopkins AL, Lai S, Haacke EM, Li D, Buckley P, Friedman L, Hedera P (1993) High resolution 2D and 3D gradient-field-echo functional imaging during finger motion demonstrates that the activation signal at 1.5 T is not from cortical parenchyma. (abstract) Tenth annual meeting of European Society for Magnetic Resonance in Medicine and Biology, p 190
Greenberg JH, Alavi A, Reivich M, Kuhl D, Uzzell B (1978) Local cerebral blood volume in response to carbon dioxide in man. Circ Res 43: 324–331
Leahy FA, Cates D, MacCallum M, Rigatto H (1980) Effect of CO2 and 100% O2 on cerebral blood flow in preterm infants. J Appl Physiol 48: 468–472
Wyatt JS, Edwards AD, Cope M, Delpy DT, McCormick DC, Potter A, Reynolds EO (1991) Response of cerebral blood volume to changes in arterial carbon dioxide tension in preterm and term infants. Pediatr Res 29: 553–557
Kuban KC, Gilles FH (1985) Human telencephalic angiogenesis. Ann Neurol 17: 539–548.
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Toft, P.B., Leth, H., Lou, H.C. et al. Local vascular CO2 reactivity in the infant brain assessed by functional MRI. Pediatr Radiol 25, 420–424 (1995). https://doi.org/10.1007/BF02019053
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DOI: https://doi.org/10.1007/BF02019053