Skip to main content
SpringerLink
Log in

Comparison of soft tissue effects of conventional ionic, low osmolar ionic and nonionic iodine containing contrast material in experimental animals

  • Originals
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

Conventional, low osmolar, and non-ionic iodine containing contrast media and saline controls were placed in the paws, muscles, and subcutaneous tissues of Sprague-Dawley rat thighs. The paw injections were observed and photographed, while the thighs were examined histologically. Results showed that although the low osmolar and non-ionic agents did produce inflammatory reactions and focal necrosis in the soft tissues, they were much better tolerated than were the conventional ionic agents. A non-ionic or low osmolar ionic contrast agent should be strongly considered when a possibility for extravasation exists.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. McAlister WH, Palmer K (1971) The histologic effects of four commonly used media for excretory urography and an attempt to modify the responses. Radiology 99:511

    PubMed  Google Scholar 

  2. Upton J, Mulliken JB, Murray JE (1979) Major intravenous extravasation injuries. Am J Surg 137:497

    PubMed  Google Scholar 

  3. Leung PC, Cheng CY (1980) Extensive local necrosis following the intravenous use of X-ray contrat medium in the upper extremity. Br J Radiol 53:361

    PubMed  Google Scholar 

  4. Grech P, Spitz L (1977) Fetal complications of amniography. Br J Radiol 50:110

    PubMed  Google Scholar 

  5. Franken EA, Grosfeld JL (1975) Unusual local reaction to iodinated contrast medium. Radiology 116:629

    PubMed  Google Scholar 

  6. Burris JA, Fairchild PG (1986) Iatrogenic hand injuries in outpatients. South Med J 79:1515

    PubMed  Google Scholar 

  7. Shelton LW (1969) Gangrenous skin defect after intrauterine transfusion. Am J Dis Child 117:593

    PubMed  Google Scholar 

  8. Thomas ML (1970) Gangrene following peripheral phlebography of the legs. Br J Radiol 43:528

    PubMed  Google Scholar 

  9. Gothlin J (1972) The comparative frequency of extravasal injection at phlebography with steel and plastic cannula. Clin Radiol 23:183

    PubMed  Google Scholar 

  10. Atilola MAO, Lumsden JH, Hulland TJ (1984) Intra-articular tissue esponse to analytical grade metrizamide in dogs. Am J Vet Res 45:2651

    PubMed  Google Scholar 

  11. Sorensen SE (1971) Changes in vascular permeability after local application of roentgen contrast media in the hamster cheek pouch. Acta Radiol 11:274

    Google Scholar 

  12. Cohan RH, Dunnick NR (1987) Intravascular contrast media: adverse reactions. AJR 149:665

    PubMed  Google Scholar 

  13. Spigos DG, Thane TT, Capek V (1977) Skin necrosis following extravasation during peripheral phlebography. Radiology 123:605

    PubMed  Google Scholar 

  14. Park JH, Kim SH, Han MC. An experimental study on tissue damage after extravasation of water soluble contrast media. International Symposium on Contrast Media, Tokyo

  15. Burd DAR, Santis G, Milward TM (1985) Severe extravasation injury: an avoidable iatrogenic diaster? Br Med J 290:1579

    Google Scholar 

  16. Smith GA (1982) Tissue necrosis following extravasation of contrast material. J Can Assoc Radiol 33:104

    PubMed  Google Scholar 

  17. Dorr RT, Alberts DS, Chen HSG (1980) Experimental model of doxorubicin extravasation in the mouse. J Pharmacol Meth 4:237

    Google Scholar 

  18. Laurie SWS, Wilson KL, Kernahan DA, Bauer BS, Vistnes LM (1984) Intravenous extravasation injuries: the effectiveness of Hyaluronidase in their treatment. Ann Plast Surg 13:191

    PubMed  Google Scholar 

  19. Cohan RH, Dunnick NR, Bashore TM (1988) Treatment of reactions to radiographic contrast media. AJR 151:263

    PubMed  Google Scholar 

  20. Loth TS, Eversmann WW (1986) Treatment methods for extravasations of chemotherapeutic agents: a comparative study. J Hand Surg 11A:388

    Google Scholar 

  21. McAlister WH, Griffith RC (1983) Cystographic contrast media: clinical and experimental studies. AJR 141:997

    PubMed  Google Scholar 

  22. McAlister WH, Shackelford GD, Kissane J (1972) The histologic effects of some iodine-containing contrast media on the rat peritoneal cavity. Radiology 105:581

    PubMed  Google Scholar 

  23. Frech RS, Davie JM, Adatepe M, Feldhaus R, McAlister WH (1970) Comparison of barium sulfate and oral 40% diatrizoate injected into the trachea of dogs. Radiology 95:299

    PubMed  Google Scholar 

  24. McAlister WH, Askin FB (1983) The effect of some contrast agents in the lung: an experimental study in the rat and dog. AJR 140:245

    PubMed  Google Scholar 

  25. Creteur V, Douglas D, Galante M, Margulis A (1983) Inflammatory colonic changes produced by contrast material. Radiology 147:77

    PubMed  Google Scholar 

  26. MacCara EM (1983) Extravasation: a hazard of intravenous therapy. Drug Intel Clin Pharm 17:13

    Google Scholar 

  27. Brown AS, Hoelzer DJ, Piercy SA (1979) Skin necrosis from extravasation of intravenous fluids in children. Plast Reconstr Surg 64:145

    PubMed  Google Scholar 

  28. Zenk KE, Dungy CI, Greene GR (1981) Nafcillin extravasation injury. Am J Dis Child 135:1113

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd, 63110, Louis, USA

    W. H. McAlister

  2. Department of Pathology, Washington University School of Medicine, 510 South Kingshighway Blvd, 63110, Louis, Mo, USA

    J. M. Kissane M.D.

Authors
  1. W. H. McAlister
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. M. Kissane M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported in part by a grant from Mallinckrodt, Inc.

Rights and permissions

Reprints and permissions

About this article

Cite this article

McAlister, W.H., Kissane, J.M. Comparison of soft tissue effects of conventional ionic, low osmolar ionic and nonionic iodine containing contrast material in experimental animals. Pediatr Radiol 20, 170–174 (1990). https://doi.org/10.1007/BF02012965

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02012965

Keywords

Search

Navigation