Abstract
Cushing's disease is the most common cause of Cushing's syndrome in children and is almost always related to over secretion of ACTH by the pituitary gland. It is important to identify a secreting adenoma prior to surgery. Seven cases studied with MRI are reviewed. In five cases the MRI findings suggested adenoma. Three secreting adenomas were confirmed at surgery. One case was in fact a cyst of the pars intermedia, and nothing could be found in the last case. Two patients presented with apparently normal findings on MRI, which was confirmed. There is a close correlation between identifying an adenoma and the success of surgery.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Lordereau I (1991) La maladie de Cushing de l'enfant et de l'adolescent: étude rétrospective à propos de 60 observations réunies à l'Hôpital Cochin et à l'Hôpital St Vincent de Paul. Medical thesis, University of Paris
Guilhaume B, Bertagna X, Thomsen M, Bricaire C, Vila-Porcile E, Olivier L, Racadot J, Derome P, Laudat MH, Girard F, Bricaire H, Luton JP (1988) Transsphenoidal pituitary surgery for the treatment of Cushing's disease: results in 64 patients and long-term follow-up studies. J Clin Endocrinol Metabol 66: 1056–1064
Nakane T, Kuwayama A, Watanabe M, Takahashi T, Kato T, Ichihara K, Kageyama N (1987) Long term results of transsphenoidal adenomectomy in patients with Cushing's disease. Neurosurgery 21: 218–222
Baleriaux D, Jacquemin C, Lemort M (1990) Imagerie par résonance magnétique de l'hypophyse et la région parasellaire. Aspect normal et pathologique. Ann Endocrinol 51: 173–180
Buchfelder M, Nistor R, Fahlbush R, Huk WJ (1993) The accuracy of CT and MR evaluation of the sella turcica for detection of adrenocorticotropic hormone-secreting adenomas in Cushing disease. AJNR 14: 1183–1190
Nichols DA, Laws ER, Houser OW, Abboud CF (1988) Comparison of magnetic resonance imaging and computed tomography in the preoperative evaluation of pituitary adenomas. Neurosurgery 22: 380–385
Dwyer AJ, Frank JA, Doppman JL, Oldfield EH, Hickey AM, Cutler GB, Loriaux DL, Schiable TF (1987) Pituitary adenomas in patients with Cushing disease: initial experience with Gd-DTPA-enhanced MR imaging. Radiology 163: 421–426
Tien RD (1992) Sequence of enhancement of various portions of the pituitary gland on gadolinium-enhanced MR images: correlation with regional blood supply, AJR 158: 651–654
Peck WW, Dillon WP, Norman D, Newton TH, Wilson CB (1989) High-resolution MR imaging of pituitary microadenomas at 1.5 T: experience with Cushing disease. AJR 152: 145–151
Orth DN, Liddle GW (1971) Results of the treatment in 108 patients with Cushing's syndrome. J Med 285: 243–247
Sakurai K, Fujita N, Harada K, Kim S, Nakanishi K, Kozuka T (1992) Magnetic susceptibility artifact in spin-echo MR imaging of the pituitary gland, AJNR 13: 1301–1308
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kalifa, G., Adamsbaum, C., Carel, J.C. et al. Diagnosis of Cushing's disease in children: A challenge for the radiologist. Pediatr Radiol 24, 547–549 (1994). https://doi.org/10.1007/BF02012728
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02012728