Abstract
Since the initial description in 1965 of Wolf syndrome, or deletion of the short arm of chromosome number four, over one hundred cases have been reported. Much less, however, has been published on the radiologic findings in this disorder. We report a case with both typical and unusual features of the 4p- syndrome, including “bottle opener” deformity of the clavicles, and review the relevant literature.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Wolf U, Reinwein H, Porsch R, Schroter R, Baitsch H (1965) Defizienz an den kurzen Armen eines Chromosoms Nr. 4. Humangenetik 1: 397
Hirschhorn K, Cooper HL (1961) Apparent deletion of short arms of one chromosome (4 or 5) in a child with defects of midline fusion. Hum Chrom Nwsl 4: 14
Keats TE, Lusted LB (1985) Atlas of roentenographic measurement, 5th edn. Year Book Medical Publishers, Chicago, p 43
Johnson VP, Mulder RD, Hosen R (1976) The Wolf-Hirschhorn (4p-) syndrome. Clin Genet 10: 104
Lazjuk GJ, Lurie JW, Ostrowskaja TI, Kirillova IA Nedzved MK, Cherstvoy ED, Silyaeva NF (1980) The Wolf-Hirschhorn syndrome. II. Pathologic anatomy. Clin Genet 18: 6
Guthrie RD, Aase JM, Asper AC, Smith DW (1971) The 4p-syndrome. Am J Dis Child 122: 421
Kitsiou S, Bartsocas CS, Alexiou D, Mourtzinis D (1986) Unusual pathologic findings in a girl with Wolf-Hirschhorn syndrome, del (4p). Pediatr Pathol 6: 161
Martsolf, JT, Chase TR, Jalal SM, Wasdahi WA (1987) Familial transmission of Wolf syndrome resulting from specific deletion 4p16 from t(4;8) (p16;p21) mat. Clin Genet 31: 366
Magill HL, Shackelford GD, McAlister WH, Graviss ER (1980) 4p- (Wolf-Hirschhorn) syndrome. Radiology 135: 283
Carter R, Baker E, Hayman D (1969) Congenital malformations associated with a ring chromosome. J Med Genet 6: 224
Citoler P, Gropp A, Gullotta F (1971) Cytogenetic and pathological observations in the (4p-) syndrome. Beitr. Path. 143: 84
Tranebjaerg L, Petersen A, Hove K, Rehder H, Mikkelsen M (1984) Clinical and cytogenetic studies in a large (4;8) translocation family with pre- and postnatal Wolf syndrome. Ann Genet 27: 224
Milkelsaar AVN, Lazjuk GJ, Lurie JW, TÜÜr S, KaÖsaar ME, Milkelsaar R,Loolaid VE (1973) A 4p- syndrome. A case report. Humangenetik 19: 345
Franceschini P, Grassi E, Marchese GS (1970) Les principaux signs radiologiques du syndrome 4p- Ann Radiol 14: 395
Gooding CA, Neuhauser EBD (1965) Growth and development of the vertebral body in the presence and absence of normal stress. AJR 93: 388
Oestreich AE (1981) The lateral clavicle hook- an acquired as well as a congenital anomaly Pediatr Radiol 11: 147
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Katz, D.S., Smith, T.H. Wolf syndrome. Pediatr Radiol 21, 369–372 (1991). https://doi.org/10.1007/BF02011492
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02011492