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Histamine influences the expression of the interleukin-6 receptor on human lymphoid, monocytoid and hepatoma cell lines

  • Histamine in the Modulation of Cell Function and Cancer
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Abstract

Based on our earlier data on the enhancing effect of histamine on the action of interleukin-6 (IL-6), we have studied the molecular mechanisms of these interactions. The effect of histamine was investigated on the binding of125I-IL-6 by B lymphoma cell line CESS, monocytoid cell line U937 and hepatoma cell line HepG2. Histamine increases the IL-6 binding by CESS cells and inhibits that by U937 and HepG2 cells. Using H1 receptor (cetirizin and loderix) and H2 receptor (cimetidine and ranitidine) specific antagonists, an H1-dependent stimulation of IL-6 binding by CESS cells was found. In contrast, down-regulation of IL-6 binding by histamine was clearly mediated through H2 receptors.

On U937 cells, using a monoclonal antibody reacting with the 80 kd chain of the human IL-6 receptor, an H2-receptor mediated inhibition of IL-6 receptor expression was found by FACS analysis.

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Authors and Affiliations

  1. Dept. of Immunology, National Institute of Rheumatology and Physiotherapy, P.O. Box 54, H-1525, Budapest 114, Hungary

    K. Merétey & A. Falus

  2. Inst. for Molecular and Cellular Biology, Div. Immunol., Osaka University, Osaka, Japan

    T. Taga & T. Kishimoto

Authors
  1. K. Merétey
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  2. A. Falus
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  3. T. Taga
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  4. T. Kishimoto
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Merétey, K., Falus, A., Taga, T. et al. Histamine influences the expression of the interleukin-6 receptor on human lymphoid, monocytoid and hepatoma cell lines. Agents and Actions 33, 189–191 (1991). https://doi.org/10.1007/BF01993163

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  • DOI: https://doi.org/10.1007/BF01993163

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