Stability of morphine hydrochloride in a portable pump reservoir
The stability of morphine hydrochloride in an admixture with sodium chloride 0.9% injection in a portable pump reservoir was investigated. Duplicate samples containing morphine hydrochloride 0.5, 1.5 and 2.5 mg/ml were stored in original 100 ml plastic drug reservoirs at 32 °C for 60 days. An amount of 3 ml was removed immediately after preparation and at fixed intervals in the weeks after. All samples were tested for loss of vehicle, for appearance of precipitation and for change in colour or pH. Furthermore, they were analysed for drug concentration using high pressure liquid chromatography. No precipitation or change in colour was observed in any of the sample admixtures. There was no change in the pH values of any of the morphine hydrochloride concentrations from day 4 and later on. Only between day 1 and day 4 a slight, but not significant rise could be detected. There was no loss of morphine hydrochloride of any importance at any concentration in the samples over 60 days when corrected for loss of vehicle. Loss of vehicle (0.8±0.1 ml a week), on the other hand, gave a rise in morphine hydrochloride concentration.
KeywordsDrug stability Infusion pumps Morphine
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- 1.Kwan JW. Use of infusion devices for epidural or intrathecal administration of spinal opioids. Am J Hosp Pharm 1990;47 Suppl 1:S18–23.Google Scholar
- 2.Tu Y, Stiles ML, Allen LV. Stability of fentanyl citrate and bupivacaine hydrochloride in portable pump reservoirs. Am J Hosp Pharm 1990;47:2037–40.Google Scholar
- 3.Kleinberg ML, Duafala ME. Stability of heroin hydrochloride in infusion devices and containers for intravenous administration. Am J Hosp Pharm 1990;47:377–81.Google Scholar
- 4.Kowalski SR, Gourlay GK. Stability of fentanyl citrate in glass and plastic containers and in a patientcontrolled delivery system. Am J Hosp Pharm 1990;47:1584–7.Google Scholar
- 5.Finley RS. Pain management with spinally administered opioids. Am J Hosp Pharm 1990;47 Suppl 1:S14–7.Google Scholar
- 6.Stiles Ml, Tu Y-H, Allen LV. Stability of morphine sulfate in portable pump reservoirs during storage and simulated administration. Am J Hosp Pharm 1989;46:1404–7.Google Scholar
- 7.Altman L, Hopkins RJ. Stability of morphine sulfate in Cormed III (Kalex) intravenous bags. Am J Hosp Pharm 1990;47:2040–2.Google Scholar
- 8.Duafala ME, Kleinberg ML, Nacov C, Flora KP, Hines J, Davis K, et al. Stability of morphine sulfate in infusion devices and containers for intravenous administration. Am J Hosp Pharm 1990;47:143–6.Google Scholar
- 9.Stiles ML, Allen LV, Tu Y. Stability of fluorouracil administered through four portable infusion pumps. Am J Hosp Pharm 1989;46:2036–40.Google Scholar