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Measurement ofN τ-methylhistamine concentrations in plasma and urine as a parameter for histamine release during anaphylactoid reactions

  • Determination and Distribution of Histamine
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Abstract

N τ-methylhistamine concentrations in plasma and urine were determined using a newly developed simultaneous determination for histamine andN τ-methylhistamine, based on isotope dilution mass fragmentography. Three groups of patients were investigated: patients receiving intravenously-administered iodamide for excretory urography, patients receiving a wasp-sting challenge, and patients treated with an intravenously-administered muscle relaxant. In all patients showing a distinct systemic anaphylactic or anaphylactoid reaction histamine andN τ-methylhistamine concentrations were found to be elevated. From the results of this study it can be concluded thatN τ-methylhistamine in plasma and urine is a good parameter for histamine release, and that the determination of this histamine metabolite are less hampered by possible artefacts (due to basophil disrupture, a very short half-life time or bacterial production) than determinations of histamine itself.

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Authors and Affiliations

  1. Bergschot Centre for Research, P.O. Box 2176, 4800 CD, Breda, The Netherlands

    J. J. Keyzer & J. G. R. de Monchy

  2. Central Laboratory of Clinical Chemistry, University Hospital, Groningen, The Netherlands

    H. Breukelman & B. G. Wolthers

  3. Department of Anesthesiology, University Hospital, Groningen, The Netherlands

    F. J. Richardson

  4. Department of Allergology, University Hospital, Groningen, The Netherlands

    J. J. Keyzer

Authors
  1. J. J. Keyzer
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  2. H. Breukelman
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  3. B. G. Wolthers
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  4. F. J. Richardson
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  5. J. G. R. de Monchy
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Keyzer, J.J., Breukelman, H., Wolthers, B.G. et al. Measurement ofN τ-methylhistamine concentrations in plasma and urine as a parameter for histamine release during anaphylactoid reactions. Agents and Actions 16, 76–79 (1985). https://doi.org/10.1007/BF01983105

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  • DOI: https://doi.org/10.1007/BF01983105

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