Abstract
The application of X-ray energy dispersive spectroscopy to detect elements collected from TPN mixtures on membrane filters has been investigated. Many simple total parenteral nutrition mixtures prepared aseptically in large bags can be stored for extended periods. Trace elements are normally excluded from such bags, because not enough is known about their long-term stability and compatibility in total parenteral nutrition mixtures. Assessing the compatibility of many trace elements by conventional methods that rely on detecting concentration changes is extremely difficult. Analysis of precipitates from total parenteral nutrition mixtures confirmed that the proposed method was capable of identifying a number of elements from the mixture in complex precipitates, including calcium, phosphorus, iron, copper and selenium.
Similar content being viewed by others
References
American Medical Association. Guidelines for essential trace element preparations for parenteral use. A statement by an expert panel. JAMA 1979;241:2051–4.
Kingsnorth AN. Trace elements in adult total-parenteral nutrition. Br J Parent Ther 1984;5:8–22.
Boddapati S, Yang K, Murty R. Intravenous solution compatibility and filter-retention characteristics of trace element preparations. Am J Hosp Pharm 1981;38:1731–6.
Allwood MC. The compatibility of four trace elements in total parenteral nutrition infusions. Int J Pharm 1983;16:57–63.
Allwood MC. Compatibility and stability of TPN mixtures in big bags. J Clin Hosp Pharm 1984;9:181–98.
Bates CG, Greiner G, Gegenheimer A. Precipitate in admixtures of new amino acid injection. Am J Hosp Pharm 1984;41:1312.
Ganther HE, Kraus RJ. Chemical stability of selenious acid in total parenteral nutrition solutions containing ascorbic acid. J Parent Enter Nutr 1989;13:185–8.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Allwood, M.C., Greenwood, M. Assessment of trace element compatibility in total parenteral nutrition infusions. Pharmaceutisch Weekblad Scientific Edition 14, 321–324 (1992). https://doi.org/10.1007/BF01977621
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01977621