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Pharmacokinetics: metabolism and renal excretion of quinolones in man

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Abstract

The quinolones are relatively poorly absorbed from the gastrointestinal tract. The elimination proceeds mainly by renal excretion. The half-life of elimination depends on the molecular structure and varies between 2 and 10 h. Impaired kidney function is expected to increase the half-life of elimination. though this effect is not always observed. Since the 4-oxo-metabolites show a higher renal clearance than the parent drug, renal impairment will result in a cumulation of the metabolites in the body.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, St. Radboud Hospital, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands

    T. B. Vree, A. M. Baars & Y. A. Hekster

  2. Department of Pulmonary Diseases, St. Radboud Hospital, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands

    W. J. A. Wijnands

  3. Farma Research, Snelliusstraat 6, 6533, NV Nijmegen, The Netherlands

    P. J. M. Guelen

  4. Department of Anaesthesiology, St. Radboud Hospital, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands

    T. B. Vree

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Vree, T.B., Wijnands, W.J.A., Guelen, P.J.M. et al. Pharmacokinetics: metabolism and renal excretion of quinolones in man. Pharmaceutisch Weekblad Scientific Edition 8, 29–34 (1986). https://doi.org/10.1007/BF01975476

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  • DOI: https://doi.org/10.1007/BF01975476

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