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Pharmacokinetics of cefuroxime in pregnant patients with preterm premature rupture of the membranes

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Abstract

To 6 pregnant patients with preterm premature rupture of the membranes, cefuroxime prophylaxis was given 1,500 mg three times daily intravenously. Cefuroxime concentrations were assayed in maternal plasma and amniotic fluid during pregnancy and in umbilical cord blood, placenta, and membranes after delivery. Our results showed a high rate of transplacental transfer of cefuroxime. Bactericidal levels could be demonstrated in maternal plasma, and in amniotic fluid leaking from the vagina. Therapeutically active levels were present in the newborns. The absorption of cefuroxime by the foetal membranes was high. Although the neonatal morbidity in this high-risk population was low, the data are still too preliminary to advise the routine prophylactic use of cefuroxime to pregnant patients with preterm premature rupture of the membranes.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, St. Elisabeth Clinic, Zandweg 180, 6418, PB Heerlen, the Netherlands

    F. J. M. E. Roumen &  P. X. J. M. Bouckaert

  2. Department of Clinical Pharmacy and Toxicology, De Wever Hospital, Henri Dunantstraat 5, 6401, CX Heerlen, the Netherlands

    H. M. H. G. Cremers

  3. Department of Clinical Pharmacy, University Hospital Nijmegen, Saint Radboud, P.O. Box 9101, 6500, HB Nijmegen, the Netherlands

    T. B. Vree

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  1. F. J. M. E. Roumen
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  2. P. X. J. M. Bouckaert
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  3. H. M. H. G. Cremers
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  4. T. B. Vree
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Roumen, F.J.M.E., Bouckaert, P.X.J.M., Cremers, H.M.H.G. et al. Pharmacokinetics of cefuroxime in pregnant patients with preterm premature rupture of the membranes. Pharmaceutisch Weekblad Scientific Edition 12, 275–279 (1990). https://doi.org/10.1007/BF01967832

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  • DOI: https://doi.org/10.1007/BF01967832

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