Skip to main content
SpringerLink
Log in

Abstracts of lectures symposium disposition and delivery of peptide drugs

  • Published:
Pharmaceutisch Weekblad Aims and scope Submit manuscript

Conclusions

A number of different processes clear peptides from the circulation. These will be described and illustrated using examples from a range of peptide hormones and analogues.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abbreviations

enk:

enkephalin

CCK:

cholecystokinin

NT:

neurotensin

SST:

somatostatin

LHRH:

luteinizing hormone-releasing hormone

AVP:

vasopressin

OXT:

oxytocin

RP:

reversed phase

AX:

anionexchange

I:

isocratic

G:

gradient

CS:

column switching

SC:

sequential columns

a):

potential in volts vs Ag/AgCl

b):

reduction followed by oxidation (dual electrode)

References

  1. Kissinger PT, Refshauge CJ, Dreiling R, Adams RN. An electrochemical detector for liquid chromatography with picogram sensitivity. Anal Lett 1973;6:465–77.

    Google Scholar 

  2. Refshauge CJ, Kissinger PT, Dreiling R, Blank L, Freeman R, Adams RN. New high performance liquid chromatographic analysis of brain catecholamines. Life Sci 1974;14:311–22.

    Article  PubMed  Google Scholar 

  3. Bennett GW, Brazell MP, Marsden CA. Electrochemistry of neuropeptides: a possible method for assay and in vivo detection. Life Sci 1981;29:1001–7.

    Article  PubMed  Google Scholar 

  4. Nabeshima T, Hiramatsu M, Noma S, Ukai M, Kameyama T. Determination of methionine enkephalin, norepinephrine, dopamine, DOPAC and HVA in brain by high-pressure liquid chromatography with electrochemical detector. Res Commun Chem Pathol Pharmacol 1982;35:421–42.

    PubMed  Google Scholar 

  5. Mousa S, Couri D. Analysis of enkephalins, β-endorphins and small peptides in their sequences by highly sensitive high-performance liquid chromatography with electrochemical detection: implications in opioid peptide metabolism. J Chromatogr 1983;267:191–8.

    Article  PubMed  Google Scholar 

  6. Sauter A, Frick W. Determination of cholecystokinin tetrapeptide and cholecystokinin octapeptide sulfate in different rat brain regions by high-pressure liquid chromatography with electrochemical detection. Anal Biochem 1983;133:307–13.

    Article  PubMed  Google Scholar 

  7. Johnson JV, Bennet GW, Marsden CA, Gardiner SM, Bennett T. Electro-chemical measurement of neurohypophyseal peptide levels in rat hypothalamic regions after adrenalectomy. Clin Exp Hypertens [A] 1984;6: 1993–8.

    Google Scholar 

  8. Fleming LH, Reynolds NC. Separation and detection of endorphins by liquid chromatography-electrochemistry. J Liq Chromatogr 1984;7:793–808.

    Google Scholar 

  9. Sauter A, Frick W. Determination of neuropeptides in discrete regions of the rat brain by high-performance liquid chromatography with electrochemical detection. J Chromatogr 1984;297:215–23.

    Article  PubMed  Google Scholar 

  10. Drumheller AL, Bachelard H, St-Pierre S, Jolicoeur FB. Determination of picomole levels of neurotensin, bombesin, and related peptide fragments using gradient elution high performance liquid chromatography coupled with electrochemical detection. J Liq Chromatogr 1985;8:1829–43.

    Google Scholar 

  11. Mousa SA, Van Loon GR. Measurement of proenkephalin A-derived peptides in biological tissues by high pressure liquid chromatography coupled with amperometric electrochemical detection. Life Sci 1985;37: 1795–802.

    Article  PubMed  Google Scholar 

  12. Sauter A, Enz A, Siegel RA. Simultaneous determination of SST, SST-28 and LHRH in rat median eminence (ME) by HPLC with electrochemical detection (ECD). Experientia 1985;41:789.

    Google Scholar 

  13. Siegel RA, Sauter A, Enz A. Determination of LHRH in rat median eminence (ME) by HPLC with electrochemical detection (ECD). Experientia 1985;41:790.

    Google Scholar 

  14. Dawson R, Steves JP, Lorden JF, Oparil S.h Reversephase separation and electrochemical detection of neuropeptides. Peptides 1985;6:1173–8.

    Article  PubMed  Google Scholar 

  15. Fleming LH, Reynolds NC. Separation and detection of closely related endorphins by liquid chromatographyelectrochemistry. J Chromatogr 1986;375:65–73.

    PubMed  Google Scholar 

  16. Garvie CT, Straub KM, Lynn RK. Quantitative liquid chromatographic determination of disulfide-containing peptide analogues of vasopressin with dual Hg/Au electrochemical detection. J Chromatogr 1987;413:43–52.

    PubMed  Google Scholar 

  17. Krull IS, Selavka CM, Duda C, Jacobs W. Derivatization and post-column reactions for improved detection in liquid chromatography/electrochemistry. J Liq Chromatogr 1985;8:2845–70.

    Google Scholar 

  18. Joseph MH, Davies P. Electrochemical activity of o-phthalaldehyde-mercapto-ethanol derivatives of amino acids. J Chromatogr 1983;277:125–36.

    PubMed  Google Scholar 

References

  1. Fridland G, Desiderio DM. Profiling of neuropeptides using gradient reversed-phase high-performance liquid chromatography with novel detection methodologies. J Chromatogr 1986;379:251–68.

    PubMed  Google Scholar 

  2. Desiderio DM. Analysis of neuropeptides by liquid chromatography and mass spectrometry. Amsterdam: Elsevier, 1984.

    Google Scholar 

  3. Tanzer FS, Tolun E, Fridland G, Dass C, Killmar J, Tinsley P, Desiderio DM. Methionine-enkephalin peptides in human teeth. Int J Pept Prot Res (in press).

  4. Takeshita H, Desiderio DM, Fridland G. Metabolic profiling of opioid peptides in canine pituitary and selected brain regions. Biomed Chromatogr 1986;1:126–39.

    Article  PubMed  Google Scholar 

  5. Ahmed MS, Randall LW, Sibai B, Dass C, Fridland G, Desiderio DM, Tolun E. Identification of dynorphin 1–8 in human placenta by mass spectrometry. Life Sci 1987;40:2067–74.

    Article  PubMed  Google Scholar 

  6. Dass C, Desiderio DM. The measurement of leucine enkephalin at the femtomole level by fast atom bombardment mass spectrometry/mass spectrometry methods. Anal Lett 1986;19:1963–71.

    Google Scholar 

  7. Dass C, Fridland G, Tinsley PW, Killmar JT, Desiderio DM. Structural characterization and quantitation of β-endorphin in human pituitary by fast atom bombardment mass spectrometry of trypsin-generated fragments. Anal Biochem (in press).

References

  1. Katsube N, Schwartz D, Needleman P. Atriopeptin turnover: quantitative relationship between in vivo changes in plasma levels and atrial content. J Pharmacol Exp Ther 1986;239:474–8.

    PubMed  Google Scholar 

  2. Murthy KK, Thibault G, Garcia R, Gutkowska J, Genest J, Cantin M. Degradation of atrial natriuretic factor in the rat. Biochem J 1986;240:461–9.

    PubMed  Google Scholar 

  3. Bennett HPJ, McMartin C. Peptide hormones and their analogues: distribution, clearance from the circulation and inactivation in vivo. Pharmacol Rev 1979;30:247–92.

    Google Scholar 

  4. Crozier IG, Nicholls MG, Ikram H, Espiner EA, Yandle TG, Jans S. Atrial natriuretic peptide in humans. Production and clearance by various tissues. Hypertension 1986;8(suppl II):11–5.

    PubMed  Google Scholar 

References

  1. Dodda Kashi S, Lee VHL. Enkephalin hydrolysis in homogenates of various absorptive mucosae of the albino rabbit: similarities in rates and involvement of aminopeptidases. Life Sci 1986;38:2019–28.

    Article  PubMed  Google Scholar 

  2. Statford RE, Lee VHL. Aminopeptidase activity in homogenates of various absorptive mucosae in the albino rabbit: implicatons in peptide delivery. Int J Pharm 1986;30:73–82.

    Article  Google Scholar 

References

  1. Burbach JPH. Action of proteolytic enzymes on lipotropins and endorphins: biosynthesis, biotransformation and fate. In: De Wied D, Gispen WH, Van Wimersma Greidanus TjB, eds. Neuropeptides and behavior. Vol. 1. Oxford: Pergamon Press, 1986:43–76.

    Google Scholar 

  2. De Wied D. Effects of peptide hormones on behavior. In: Ganong WF, Martini L, eds. Frontiers in neuroendocrinology. London: Oxford University Press, 1969:97–140.

    Google Scholar 

  3. De Wied D. Neurohypophyseal hormone influences on learning and memory processes. In: Lynch G, McCaugh JL, Weinberger NM, eds. Neurobiology of learning and memory. New York: Guilford Press, 1984:289–312.

    Google Scholar 

  4. De Wied D. The neuropeptide concept. Progr Brain Res 1987;72:93–108.

    Google Scholar 

  5. De Wied D, Jolles J. Neuropeptides derived from proopiocortin: behavioural, physiological, and neurochemical effects. Physiol Rev 1982;62:976–1059.

    PubMed  Google Scholar 

  6. Gispen WH, Isaacson RL. Excessive grooming in response to ACTH. In: De Wied D, Gispen WH, Van Wimersma Greidanus TjB, eds. Neuropeptides and behavior. Vol. 1. Oxford: Pergamon Press, 1986:273–312.

    Google Scholar 

  7. Strand FL, Smith CM. LPH, ACTH, MSH and motor systems. In: De Wied D, Gispen WH, Van Wimersma Greidanus TjB, eds. Neuropeptides and behavior. Vol. 1. Oxford: Pergamon Press, 1986:245–72.

    Google Scholar 

  8. Swaab DF, Martin JT. Functions of α-melanotropin and other opiomelanocortin peptides in labour, intrauterine growth and brain development. In: Evered D, Lawrenson G, eds. Peptides of the pars intermedia. Ciba Foundation Symposium 81. London: Pitman Medical, 1981:196–217.

    Google Scholar 

  9. Van Ree JM. Non-opiate β-endorphin fragments and dopamine II. β-Endorphin 2–9 enhances apomorphineinduced stereotype following subcutaneous and intrastriatal injection. Neuropharmacology 1982;21:1103–9.

    Article  PubMed  Google Scholar 

References

  1. Lundin S, Melin P, Vilhardt H. Plasma concentrations of 1-deamino-8-D-arginine vasopressin after intragastric administration in the rat. Acta Endocrinol 1985; 108:179–83.

    PubMed  Google Scholar 

  2. Lundin S, Vilhardt H. Absorption of intragastrically administered DDAVP in conscious dogs. Life Sci 1986;38:703–9.

    Article  PubMed  Google Scholar 

  3. Vilhardt H, Lundin S. In vitro intestinal transport of vasopressin and its analogues. Acta Physiol Scand 1986;126:601–7.

    PubMed  Google Scholar 

  4. Lundin S, Vilhardt H. Absorption of 1-deamino-8-D-arginine vasopressin from different regions of the gastrointestinal tract in rabbits. Acta Endocrinol 1986;112:-457–60.

    PubMed  Google Scholar 

  5. Vilhardt H, Lundin S, Falck J. Biological effect and plasma concentrations of DDAVP after intranasal and peroral administration to humans. Gen Pharmacol 1986;17:481–3.

    PubMed  Google Scholar 

References

  1. Harris AS, Nilsson IM, Wagner ZG, Alkner U. Intranasal administration of peptides: nasal deposition, biological response, and absorption of desmopressin. J. Pharm Sci 1986;11:1085–8.

    Google Scholar 

  2. Harris AS. Biopharmaceutical aspects on the intranasal administration of peptides. In: Davis SS, Illum L, Tomlinson E, eds. Delivery systems for peptide drugs. New York: Plenum Press, 1986:191–204.

    Google Scholar 

  3. Salzman R, Manson JE, Griffing GT, Kimmerle R, Ruderman N, McCall A, Stoltz EI, Mullin C, Small R, Armstrong J, Melby JC. Intranasal aerosolized insulin: mixed-meal studies and long-term use in type I Diabetes. N Engl J Med 1985;312:1078–84.

    PubMed  Google Scholar 

References

  1. Muranishi S. Modification of intestinal absorption of drugs by lipoidal adjuvants. Pharm Res 1985;2:108–18.

    Article  Google Scholar 

Literature

  1. Rudman CG, Parsons JA. Transdermal uptake of a peptide hormone: inhibition by calcitonin eardrops of induced osteolysis in guinea-pig ossicles. Experientia 1979;35:521–2.

    PubMed  Google Scholar 

  2. Hurkmans JFGM, Boddé HE, Van Driel LMJ, Van Doorne H, Junginger HE. Skin irritation caused by transdermal drug delivery systems during long-term (5 days) application. Br J Dermatol 1985;112:461–7.

    PubMed  Google Scholar 

  3. Roorda WE, Boddé HE, Bouwstra JA, De Boer AG, Junginger HE. Synthetic hydrogels as drug delivery systems. Pharm Weekbl [Sci] 1986;8:165–89.

    Google Scholar 

References

  1. Worthy W. Versatile microporous polymers developed. Chem Engl News 1978;56:23–4.

    Google Scholar 

  2. Schneider K. Mikroporöse Polymere. Kunststoffe 1981; 71:183–4.

    Google Scholar 

  3. Boer GJ, Kruisbrink J, Van Pelt-Heerschap H. Longterm and constant release of vasopressin from Accurel tubing: implantation in the Brattleboro rat. J Endocrinol 1983;98:147–52.

    PubMed  Google Scholar 

  4. Kruisbrink J, Boer GJ. Controlled long-term release of small peptide homones using a new microporous polypropylene polymer: its application for vasopressin in the Brattleboro rat and potential perinatal use. J Pharm Sci 1984;73:1713–8.

    PubMed  Google Scholar 

  5. Boer GJ, Kruisbrink J. A polymeric controlled drug delivery device for peptides based on a surface desorption/diffusion mechanism. Biomaterials 1987;8:265–74.

    Article  PubMed  Google Scholar 

  6. Kruisbrink J, Boer GJ. The use of [3H] vasopressin for in vivo studies of controlled delivery from an Accurel/ collodion device in the Brattleboro rat. J Pharm Pharmacol 1986;38:893–7.

    PubMed  Google Scholar 

References

  1. Kwong AK, Chou S, Sun AM, Sefton MV, Goosen MFA. In vitro and in vivo release of insulin from poly (lactic acid) microbeads and pellets. J Control Rel 1986; 4:47–62.

    Article  Google Scholar 

  2. Lin SY, Ho LT, Chiou HL. Microencapsulation and controlled release of insulin from polylactic acid microcapsules. Biomater Med Devices Artif Organs 1986;13: 187–201.

    Google Scholar 

References

  1. Alving CR. Delivery of liposome encapsulated drugs to macrophages. Pharmacol Ther 1983;22:407–34.

    Article  PubMed  Google Scholar 

  2. Pastan I, Willingham MC. Receptor-mediated endocytosis: coated pits, receptosomes and the Golgi. Trends Biochem Sci 1983;8:250–4.

    Article  Google Scholar 

  3. Patel HM, Ryman BE. Chapter 11. In: Knigh CG, ed. Liposomes: from physical structure to therapeutic application. Amsterdam: Elsevier, 1981:409–41.

    Google Scholar 

  4. Patel HM, Tuzel NS, Stevenson RW. Intracellular digestion of saturated and unsaturated phospholipid liposomes by mucosal cells: possible mechanism of transport of liposomally entrapped macromolecules across the isolated vascularly perfused rabbit ileum. Biochim Biophys Acta 1985;839:40–9.

    PubMed  Google Scholar 

  5. Schroit AJ, Galligioni E, Fidler IJ. Factors influencing the in situ activation of macrophages by liposomes containing muramyl dipeptide. Biol Cell 1983;47:87–94.

    Google Scholar 

  6. Wild A. Transport of immunoglobulins and other proteins from mother to young. In: Dingle JT, ed. Liposomes in biology and pathology. Amsterdam: Elsevier, 1983:169–233.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Organon Scientific Development Group, P.O. Box 20, 5340 BG, Oss, the Netherlands

    J. W. van Nispen

  2. Merck Sharp & Dohme Research Laboratories, 19486, West Point, PA, USA

    M. Hichens

  3. Preclinical Research, 386/743 co Sandoz Ltd., CH-4002, Basle, Switzerland

    A. Sauter

  4. Center for Bio-Pharmaceutical Sciences, Division of Analytical Chemistry, Leiden University, P.O. Box 9502, 2300, RA Leiden, The Netherlands

    H. Lingeman

  5. University of Tennessee, 38163, Memphis, 800 Madison Avenue, Tennessee, USA

    D. C. Cubbins

  6. Research Department, Ciba-Geigy Co., 07901, Summity, NJ, USA

    C. McMartin, R. L. Webb, L. P. Wennogle, H. E. Wysowskyi & M. B. Zimmerman

  7. University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA, USA

    V. H. L. Lee

  8. Hoechst AG, D-6230, Frankfurt 80, Germany

    J. Sandow, H. Seidel & R. Schmiedel

  9. Department of Pharmaceutical Chemistry, University of Kansas, 66045, Lawrence, KS, USA

    Bradley T. Keller, Kevin R. Smith & Ronald T. Borchardt

  10. Psychoneuroendocrinology Laboratory (151), Veterans Administration Medical Center and Tulane University School of Medicine, 70146, New Orleans, LA, USA

    W. A. Banks & A. J. Kastin

  11. College of Pharmacy, University of Kentucky, 40536-0082, Kentucky, Lexington, USA

    D. de Wied

  12. School of Pharmacy, University of Wisconsin, 53706, Madison, Wisconsin, USA

    P. P. DeLuca

  13. Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden

    J. R. Robinson

  14. Department of Medical Physiology C, University of Copenhagen, Denmark

    S. Lundin

  15. Department of Biochemistry, Medical College of Ohio, 43699, Toledo, Ohio, USA

    H. Vilhardt

  16. Ferring Pharmaceuticals, S-200 62, Malmö, Sweden

    M. Saffran, G. S. Kumar, D. G. Neckers, F. Williams & J. B. Field

  17. Diabetes Unit, Beth Israel Hospitalabetes Unit, Beth Israel Hospital Unit, Harvard Medical School, 02215, Boston, MA, USA

    R. H. Jones & A. S. Harris

  18. Kyoto Pharmaceutical University, Misasagi, Yamanshinaku, Kyoto, Japan

    L. Panepinto & Alan C. Moses

  19. Center for Bio-Pharmaceutical Sciences, P.O. Box 9502, 2300, RA Leiden, the Netherlands

    S. Muranishi

  20. Dermatology Department, University Hospital, 2333, AA Leiden, the Netherlands

    H. E. Boddé & J. Verhoef

  21. Smith Kline & French Labs. R & D, Department of Drug Delivery, 709 Swedeland Road, 19479, Swedeland, PA, USA

    M. Ponec

  22. Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam ZO, the Netherlands

    Gary G. Liversidge

  23. Organon International BV, P.O. Box 20, Oss, the Netherlands

    G. J. Boer & J. Kruisbrink

  24. Department of Biochemistry, Charing Cross and Westminster Medical School, Fulham Palace Road, W6 8RF, London, UK

    H. de Nijs, T. R. M. Bouwman, M. J. D. Eenink & Harish M. Patel

Authors
  1. J. W. van Nispen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Hichens
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Sauter
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Lingeman
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. C. Cubbins
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. McMartin
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. L. Webb
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. L. P. Wennogle
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. H. E. Wysowskyi
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. M. B. Zimmerman
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. V. H. L. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. J. Sandow
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. H. Seidel
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. R. Schmiedel
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Bradley T. Keller
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Kevin R. Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Ronald T. Borchardt
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. W. A. Banks
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. A. J. Kastin
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. D. de Wied
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. P. P. DeLuca
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. J. R. Robinson
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. S. Lundin
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. H. Vilhardt
    View author publications

    You can also search for this author in PubMed Google Scholar

  25. M. Saffran
    View author publications

    You can also search for this author in PubMed Google Scholar

  26. G. S. Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  27. D. G. Neckers
    View author publications

    You can also search for this author in PubMed Google Scholar

  28. F. Williams
    View author publications

    You can also search for this author in PubMed Google Scholar

  29. J. B. Field
    View author publications

    You can also search for this author in PubMed Google Scholar

  30. R. H. Jones
    View author publications

    You can also search for this author in PubMed Google Scholar

  31. L. Panepinto
    View author publications

    You can also search for this author in PubMed Google Scholar

  32. A. S. Harris
    View author publications

    You can also search for this author in PubMed Google Scholar

  33. Alan C. Moses
    View author publications

    You can also search for this author in PubMed Google Scholar

  34. S. Muranishi
    View author publications

    You can also search for this author in PubMed Google Scholar

  35. H. E. Boddé
    View author publications

    You can also search for this author in PubMed Google Scholar

  36. M. Ponec
    View author publications

    You can also search for this author in PubMed Google Scholar

  37. J. Verhoef
    View author publications

    You can also search for this author in PubMed Google Scholar

  38. Gary G. Liversidge
    View author publications

    You can also search for this author in PubMed Google Scholar

  39. G. J. Boer
    View author publications

    You can also search for this author in PubMed Google Scholar

  40. J. Kruisbrink
    View author publications

    You can also search for this author in PubMed Google Scholar

  41. H. de Nijs
    View author publications

    You can also search for this author in PubMed Google Scholar

  42. T. R. M. Bouwman
    View author publications

    You can also search for this author in PubMed Google Scholar

  43. M. J. D. Eenink
    View author publications

    You can also search for this author in PubMed Google Scholar

  44. Harish M. Patel
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

van Nispen, J.W., Hichens, M., Sauter, A. et al. Abstracts of lectures symposium disposition and delivery of peptide drugs. Pharmaceutisch Weekblad Scientific Edition 10, 30–50 (1988). https://doi.org/10.1007/BF01966433

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01966433

Keywords

Search

Navigation