Abstract
The effect of food on the movement of pellets in the gastro-intestinal tract was investigated in seven volunteers, either by means of X-rays taken after oral administration of barium sulfate pellets or by means of saliva concentration profiles of lithium obtained after oral administration of lithium sulfate controlled-release pellets. The X-ray studies showed that food had an effect on the time required for the pellets to leave the stomach and on their degree of dispersion in the small intestine, but not on other parameters. The studies with the lithium sulfate controlled-release pellets showed that food had a significant effect only in one in three subjects.
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Galeone M, Nizzola L, Cacioli D, Moise G.In vivo demonstration of delivery mechanisms from sustainedrelease pellets. Curr Ther Res 1981;29:217–34.
Block BP, Thomas MB. A method for testing intestinal irritancy of sustained release KCl preparations in animals. J Pharm Pharmacol 1978;30:70P.
Beckett AH, Samaan AC, Ellis AC. Sustained release KCl products:in vitro-in vivo correlations. J Pharm Pharmacol 1978;30:69P.
Beckett AH. Controlled-release dosage forms. Pharm J 1983;Oct 8:402.
Bechgaard H, Christensen FN. Physiological factors and controlled release dosage forms. Pharm J 1982;229:373–6.
Beckett AH. Controlled release dosage forms. Pharm J 1983;Nov 5:538.
Feinblatt TM, Ferguson EA. Timed-disintegration capsules. Anin vivo roentgenographic study. N Engl J Med 1956;254:940–7.
Davis SS, Hardy JG, Taylor MJ, Whalley DR, Wilson G. The effect of food on the gastrointestinal transit of pellets and an osmotic device (Osmet). Int J Pharm 1984;21:331–40.
O'Reilly S, Wilson CG, Hardy JG. The influence of food on the gastric emptying of multiparticulate dosage forms. Int J Pharm 1987;34:213–6.
Davis SS, Khosla R, Wilson CG, Washington N. Gastrointestinal transit of a controlled-release pellet formulation of tiaprofenic acid and the effect of food. Int J Pharm 1987;35:253–8.
Kyroudis A.In vivo/in vitro correlation in rate-controlled drug delivery [Dissertation]. London: University of London, 1984:301–8.
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Kyroudis, A., Markantonis, S.L. & Beckett, A.H. The effect of food on the movement of pellets in the gastro-intestinal tract. Pharmaceutisch Weekblad Scientific Edition 11, 44–49 (1989). https://doi.org/10.1007/BF01962974
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DOI: https://doi.org/10.1007/BF01962974