Pharmaceutisch Weekblad

, Volume 5, Issue 4, pp 129–130 | Cite as

The composition of the essential oil in the leaves of Coleus aromaticus Bentham and their importance as a component of the Species antiaphthosae Ph. Ned. Ed. V

  • R. Bos
  • H. Hendriks
  • F. H. L. van Os
Original Articles


The leaves ofColeus aromaticus Bentham were used in the East Indian archipelago, mainly in cases of aphthous stomatitis. For this purpose the Dutch Pharmacopoeia Ed. v introduced the Species antiaphthosae withColeus leaves as an active component, because of their antiseptic qualities. Older research ascribed this activity to carvacrol and perhaps thymol. However, in more recent research in India eugenol and methyleugenol were also found to occur in this oil. Our investigations on original leaves from Java byGC-MS showed the absence of eugenol and methyleugenol, which leads us to the conclusion that on Java another chemotype occurs.


Public Health Internal Medicine Active Component Eugenol Stomatitis 
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1983

Authors and Affiliations

  • R. Bos
    • 1
  • H. Hendriks
    • 1
  • F. H. L. van Os
    • 1
  1. 1.Laboratory of PharmacognosyState University of GroningenAW GroningenThe Netherlands

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