Pharmaceutisch Weekblad

, Volume 5, Issue 4, pp 121–128 | Cite as

Receptors: the materialization of a concept

  • E. J. Ariëns
Review Articles


The evolution of the receptor concept over the years, culminating in the materialization thereof is outlined step by step. Attention is paid to molecular pharmacology, affinity and intrinsic activity, partial agonists and partial antagonists, receptor differentiation, receptor kinetics, receptor dynamics, receptor-effector coupling and receptor reserve, localization, quantification and isolation of receptors. Receptor pathology includes ‘inborn errors of receptor function’, involvement of receptors in autoimmune diseases and in malignant diseases. Finally iatrogenic receptor imbalances are discussed.


Public Health Internal Medicine Autoimmune Disease Malignant Disease Receptor Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1983

Authors and Affiliations

  • E. J. Ariëns
    • 1
  1. 1.Institute for PharmacologyCatholic University of NijmegenEZ Nijmegen

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