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Etoposide and teniposide

Bioanalysis, metabolism and clinical pharmacokinetics

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Abstract

Etoposide (VP 16-213) and teniposide (VM 26) are semisynthetic epipodophyllotoxin derivatives active against a variety of tumours. The clinical efficacy has led to an increasing interest in these compounds. This review presents information on the mechanism of action, biochemical pharmacology, bioanalysis, metabolism and pharmacokinetics of etoposide and teniposide.

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  1. J. J. M. Holthuis

    Present address: EuroCetus BV, Stravinskylaan 357, 1077 XX, Amsterdam, The Netherlands

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  1. Department of Pharmaceutical Analysis, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, the Netherlands

    J. J. M. Holthuis

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Holthuis, J.J.M. Etoposide and teniposide. Pharmaceutisch Weekblad Scientific Edition 10, 101–116 (1988). https://doi.org/10.1007/BF01959294

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