Pharmaceutisch Weekblad

, Volume 4, Issue 5, pp 154–158 | Cite as

Angiotensin converting enzyme inhibitors

  • W. Soudijn
Medicinal Chemistry Congress


Inhibition of angiotensin converting enzyme (scace) in patients suffering from renovascular hypertension results in lowering of the blood-pressure. The development of captopril, an orally activeace inhibitor and the structure-activity relationship of captopril analogues are described. Some side effects of captopril were attributed to the presence of an SH-group in the molecule. This led to the development of a series of non-mercaptoace inhibitors derived from captopril. One of them, enalapril, a potentace inhibitor with a long duration of antihypertensive action, is now tested in clinical trials.


Public Health Hypertension Clinical Trial Internal Medicine Angiotensin 
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1982

Authors and Affiliations

  • W. Soudijn
    • 1
  1. 1.Dept. of Pharmaceutical ChemistryUniversity of AmsterdamTV AmsterdamThe Netherlands

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