Pharmaceutisch Weekblad

, Volume 4, Issue 5, pp 139–145 | Cite as

Mianserin: result of a decade of antidepressant research

  • J. J. De Ridder
Medicinal Chemistry Congress


Mianserin is a new tetracyclic compound being the active principle of the antidepressant drug Tolvon®. Originally synthesized as an antiallergic, the discovery of the antidepressant activity of mianserin was serendipitous.

This review describes the historical development of mianserin as the first representative of a second generation of antidepressants. A summary is given of the clinical trials performed leading to a therapeutic profile of an antidepressant of similar efficacy as tricyclic products, however, with fewer and less severe side effects. Unlike tricyclic products mianserin lacks cardiotoxicity resulting in a superior safety also in overdosage.


Public Health Clinical Trial Internal Medicine Historical Development Tricyclic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1982

Authors and Affiliations

  • J. J. De Ridder
    • 1
  1. 1.Organon International BVBH OssThe Netherlands

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