Pharmaceutisch Weekblad

, Volume 4, Issue 5, pp 135–136 | Cite as

Plasma progesterone levels after using high dose suppositories. A preliminary report

  • Y. G. Van Der Meer
  • A. C. Van Loenen
  • E. W. Loendersloot
  • L. J. B. Jaszmann
Short Communications


Rectal administration of progesterone in relatively high doses is sometimes advocated for a few gynaecological disorders. Two different kinds of suppositories, containing 200 mg of active substance in a fatty base, were administered to six volunteers. The progesterone plasma concentrations, measured at 1, 2 and 6 hours after administration, showed large interindividual differences. However, the average concentrations did not differ significantly between the two kinds of suppositories. The concentrations reached are in the order of magnitude of the normal top levels in the second half of the menstrual cycle.


Public Health Internal Medicine Plasma Concentration Progesterone Menstrual Cycle 
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1982

Authors and Affiliations

  • Y. G. Van Der Meer
    • 1
  • A. C. Van Loenen
    • 1
  • E. W. Loendersloot
    • 2
  • L. J. B. Jaszmann
    • 3
  1. 1.Hospital Pharmacy Bennekom/EdeGA BennekomThe Netherlands
  2. 2.Department of Obstetrics and GynaecologyPieter Pauw HospitalWageningenThe Netherlands
  3. 3.Department of Obstetrics and GynaecologyRegional Protestant HospitalBennekomThe Netherlands

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