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Cholinergic mechanisms in the production of focal cortical slow waves

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Summary

Microiontophoretic application of scopolamine and atropine usually induced or increased focal cortical slow waves of under 3 Hz and abolished or decreased focal fast waves of over 6 Hz whereas acetylcholine iontophoresis and electrical stimulation of the mesencephalic reticular formation had the opposite effect, suggesting that focal cortical slow waves may be due to the interruption of cholinergic input from the reticular formation.

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Authors and Affiliations

  1. Neurology Service, VA Lakeside Medical Center, 333 East Huron Street, 60611, Chicago, IL, USA

    R. Spehlmann & K. Norcross

  2. Departments of Neurology and Pharmacology, Northwestern University Medical School, 60611, Chicago, IL, USA

    R. Spehlmann & K. Norcross

Authors
  1. R. Spehlmann
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  2. K. Norcross
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Additional information

This study was supported by funds from the Veterans Administration and by NIH research grant NS 06820.

We thank Mr C.C. Smathers, Jr, for his technical help.

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Spehlmann, R., Norcross, K. Cholinergic mechanisms in the production of focal cortical slow waves. Experientia 38, 109–111 (1982). https://doi.org/10.1007/BF01944557

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