Skip to main content
SpringerLink
Log in

ANF-Konzentrationen und Drücke im kleinen Kreislauf unter Belastung vor und nach Koronardilatation

Exercise induced increase of atrial natriuretic factor plasma concentration and pulmonary artery pressure before and after coronary angioplasty

  • Originalien
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

According to several reports of close correlations between pulmonary artery pressure and ANF plasma levels it would be convenient to replace invasive pressure monitoring by ANF determination.

Mean pulmonary artery and right atrial pressures and pulmonary artery as well as peripheral venous ANF plasma concentrations were measured in 24 patients before and after coronary angioplasty (PTCA) continuously at rest and during exercise: At rest, both pressure and ANF-values remained unchanged before and after PTCA. At exercise, there was a decrease of mean pulmonary artery pressure (from 41.3±8.6 to 31.5±7.4 mmHg,p<0.001), mean right atrial pressure (from 11.9±3.0 to 9.0±2.3 mmHg,p< 0.001), pulmonary artery (282.5±191.0 to 207.3±157.2 pg/ml,p<0.05) and peripheral venous (112.7±48.0 to 97.1±53.2 pg/ml, n.s.) ANF concentration after PTCA. We found no correlation between PTCA-induced changes of right arterial pressures and ANF concentrations, while changes of pulmonary artery pressures were significantly correlated to changes of peripheral venous (r=0.79,p<0.001) as well as pulmonary artery (r=0.59,p<0.01) ANF concentrations at exercise. In 6 of the 24 patients, however there was an inverse relationship between changes of pulmonary artery pressures and ANF concentrations. — Our data demonstrate a significant correlation between changes of ANF plasma level and pulmonary artery pressure values at exercise after PTCA. In the individual case however invasive pressure monitoring cannot be replaced by determination of ANF plasma levels.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

ANF:

Atrialer natriuretischer Faktor

PTCA:

Perkutane transluminale Koronarangioplastie

PPa:

mittlerer pulmonalarterieller Druck

PPc:

mittlerer pulmonalcapillärer Druck

PRA:

mittlerer rechtsatrialer Druck

Literatur

  1. Bates ER, Shenker Y, Grekin RJ (1986) The relationship between plasma levels of immunoreactive atrial natriuretic hormone and hemodynamic function in man. Circulation 73:1155–1161

    Google Scholar 

  2. Dietz R, Purgaj J, Lang RE, Schömig A (1986) Pressure dependent release of atrial natriuretic peptide (ANP) in patients with cronic cardiac diseases: does it reset? Klin Wochenschr 64 (Suppl VI):42–46

    Google Scholar 

  3. Donckier JE, De Coster PM, Buysschaert M, Levecque P, Cauwe FM, Brichant CM, Berbinschi AC, Ketelslegers JM (1988) Effect of exercise on plasma atrial natriuretic factor and cardiac function in men and women. Eur J Clin Invest 18:415–419

    Google Scholar 

  4. Eisenhauer T, Talartschik J, Scheler F (1986) Direction of fluid overload by plasma concentration of human atrial natriuretic peptide (h-ANP) in patients with renal failure. Klin Wochenschr 64 (Suppl VI):68–72

    Google Scholar 

  5. Espiner EA, Crozier IG, Nicholls MG, Cuneo R, Yandle TG, Ikram H (1985) Cardiac secretion of atrial natriuretic peptide. Lancet II:398–399

    Google Scholar 

  6. Follenius M, Brandenberger G (1988) Increase in atrial natriuretic peptide in response to physical exercise. Eur J Appl Physiol 57:159–162

    Google Scholar 

  7. Fyhrquist F, Töttermann KJ, Tikkanen I (1986) Exercise related release of atrial natriuretic peptide in healthy subjects. Hypertension 8:823

    Google Scholar 

  8. Goetz KL (1987) Atrial natriuretic peptide and atrial pressure. N Engl J Med 316:485

    Google Scholar 

  9. Hartter E, Woloszczuk W, Stummvoll HK (1986) Radioimmunoassay of atrial natriuretic peptides in human plasma. Clin Chem 32:441–445

    Google Scholar 

  10. Haufe MC, Weil J, Heim JM, Ernst JE, Gerzer R, Theisen K (1989) Hämodynamische und medikamentöse Beeinflussung der stimulierten ANF-Sekretion. Z Kardiol 78:532–537

    Google Scholar 

  11. Hu DCK, Wong EFC, Wong NLM (1988) The differential response in atrial natriuretic peptide release during exercise in patients with and without ischemic heart disease. Am J Med Sci 296:111–113

    Google Scholar 

  12. Lang RE, Thölken H, Ganten D, Luft FC, Ruskoaho H, Unger T (1985) Atrial natriuretic factor — a circulating hormone stimulated by volume loading. Nature 314:264–266

    Google Scholar 

  13. Müller FB, Erne P, Raine AEG, Kiowski W, Resink TJ, Burkart F, Bühler FR (1986) Sekretion des atrialen natriuretischen Peptids: Abhängigkeit vom Vorhofdruck und systemischen Blutdruck. Schweiz Med Wochenschr 116:1610–1612

    Google Scholar 

  14. Nishikimi T, Kohno M, Matsuura T, Akioka T, Teragaki M, Yasuda M, Oku H, Takeuchi K, Takeda T (1986) Effect of exercise on circulating atrial natriuretic polypeptide in valvular heart disease. Am J Cardiol 58:1119–1120

    Google Scholar 

  15. Nishikimi T, Kohno M, Itagane H, Hirota K, Akioka K, Teragaki M, Yasuda M, Oku H, Takeuchi K, Takeda T (1988) Influence of exercise on plasma atrial natriuretic factor levels in patients with myocardial infarction. Am Heart J 115:753–760

    Google Scholar 

  16. Ogawa K, Ito T, Hashimoto H, Ito Y, Ohno O, Tsuboi H, Takasu N, Tanahashi T, Satake T (1986) Plasma atrial natriuretic factor in congestive heart failure. Lancet I:106

    Google Scholar 

  17. Ogihara T, Shima J, Hara H, Kumahara Y, Kangawa K, Matsuo H (1986) Changes in human plasma atrial natriuretic polypeptide concentration in normal subjects during passive leg raising. Clin Sci 71:147–150

    Google Scholar 

  18. Osborn MJ, Hammill SC, Burnett JC (1986) Enhanced levels of circulating atrial natriuretic peptide during ventricular pacing in humans. J Am Coll Cardiol 7:192

    Google Scholar 

  19. Pettersson A, Rickstein SE, Towle AC, Hedner J, Hedner T (1985) Effect of blood volume expansion and sympatic denervation on plasma levels of atrial natriuretic factor (ANF) in the rat. Acta Physiol Scand 124:309–311

    Google Scholar 

  20. Petzl DH, Hartter E, Osterode W, Böhm H, Woloszczuk W (1987) Atrial natriuretic peptide release due to physical exercise in healthy persons and in cardiac patients. Klin Wochenschr 65:194–196

    Google Scholar 

  21. Raine AEG, Erne P, Bürgisser E, Müller FB, Bolli P, Burkart F, Bühler FR (1986) Atrial natriuretic peptide and atrial pressure in patients with congestive heart failure. N Engl J Med 315:533–537

    Google Scholar 

  22. Richards AM, Tonolo G, Cleland JGF, McIntyre GD, Leckie BJ, Dargie HJ, Ball SG, Robertson JIS (1987) Plasma atrial natriuretic peptide concentrations during exercise in sodium replete and deplete normal man. Clin Sci 72:159–164

    Google Scholar 

  23. Rodeheffer RJ, Tanaka I, Imada T, Hollister AS, Robertson D, Inagami T (1986) Atrial pressure and secretion of atrial natriuretic factor into the human central circulation. J Am Coll Cardiol 8:18–26

    Google Scholar 

  24. Sasaki A, Kida O, Kangawa K, Matsuo H, Tanaka K (1986) Involvement of sympathetic nerves in cardiosuppressive effects of a-human atrial natriuretic polypeptide (a-h ANP) in anesthetized rats. Eur J Pharmacol 120:345–349

    Google Scholar 

  25. Sato F, Kamoi K, Wakiya Y, Ozawa T, Arai O, Ishibashi M, Yamaji T (1986) Relationship between plasma atrial natriuretic peptide levels and atrial pressure in man. J Clin Endocrinol Metab 63:823–827

    Google Scholar 

  26. Scholz KH, Bauer B, Herrmann Ch, Spaar U, Tebbe U, Neuhaus KL, Kreuzer H (1989) ANF-Plasmavariabilität bei wiederholter maximaler körperlicher Belastung. Z Kardiol 78 (Suppl 1):16

    Google Scholar 

  27. Sigwart U, Grbic M, Essinger A, Bischof-Delaloye A, Sadeghi A, Rivier JL (1982) Improvement of left ventricular function after percutaneous transluminal coronary angioplasty. Am J Cardiol 49:651–657

    Google Scholar 

  28. Singer D, Dean J, Buckley M, Sagnella GA, Mac Gregor GA (1987) Secretion of atrial natriuretic peptide from the heart in man. Br Heart J 58:24–28

    Google Scholar 

  29. Somers VK, Anderson JV, Conway J, Sleight P, Bloom SR (1986) Atrial natriuretic peptide is released by dynamic exercise in man. Horm Metabol Res 18:871–872

    Google Scholar 

  30. Thoren P, Mark AL, Morgan DA, O'Neill TP, Needleman P, Brody MJ (1986) Activation of vagal depressor reflexes by atrio-peptins inhibits renal sympatic nerve activity. Am J Physiol 251:1252–1259

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Zentrum Innere Medizin, Abteilung Kardiologie und Pulmonologie, Universitätsklinik Göttingen, Deutschland

    K. H. Scholz, J. Marten, Ch. Herrmann, U. Spaar, U. Tebbe, K. L. Neuhaus & H. Kreuzer

Authors
  1. K. H. Scholz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Marten
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ch. Herrmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. U. Spaar
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. U. Tebbe
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. L. Neuhaus
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. H. Kreuzer
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Herrn Prof. Dr. med F. Scheler zum 65. Geburtstag gewidmet

Rights and permissions

Reprints and permissions

About this article

Cite this article

Scholz, K.H., Marten, J., Herrmann, C. et al. ANF-Konzentrationen und Drücke im kleinen Kreislauf unter Belastung vor und nach Koronardilatation. Klin Wochenschr 68, 823–829 (1990). https://doi.org/10.1007/BF01796272

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01796272

Key words

Search

Navigation