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Pulmonary and haemodynamic effects of extracorporeal circulation in the cat and the beneficial effects of prostacyclin

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Abstract

Side-effects of a veno-venous extracorporeal system and possible beneficial effects of prostacyclin (epoprostenol) are analyzed on the cat. Three groups were studied; one control group without extracorporeal circulation and two groups with an extracorporeal flow of 10–12 ml/kg/min, one of which was given prostacyclin (70–110 ng/kg/min). The extracorporeal circulation triggered a decrease in arterial saturation (from 99 to 91 %) and carbon dioxide elimination (increase in arterial to end-tidal PCO2 by about 1 kpa) a metabolic acidosis (pH≈7.20), a platelet consumption (≈50%) and shortened survival time, side-effects reduced by prostacyclin. Further, there was a marked increase in haemoglobin concentration indicating hypovolemia via capillary fluid filtration. None of these side-effects were seen in the control group. Extracorporeal circulation as a trigger for pulmonary dysfunction and for impaired tissue nutrition with possible beneficial effects of prostacyclin is discussed, and also from a clinical point of view (i.e. extracorporeal lung assistance, ECLA), on the basis of the results.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, University and University Hospital of Lund, Sölvegatan 19, S-223 62, Lund, Sweden

    J. Jahr &  P. O. Grände

  2. Department of Anaesthesia, University and University Hospital of Lund, Sweden

    J. Jahr &  P. O. Grände

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  1. J. Jahr
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  2. P. O. Grände
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Jahr, J., Grände, P.O. Pulmonary and haemodynamic effects of extracorporeal circulation in the cat and the beneficial effects of prostacyclin. Intensive Care Med 18, 118–122 (1992). https://doi.org/10.1007/BF01705045

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  • DOI: https://doi.org/10.1007/BF01705045

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