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Evaluation hämatologischer Nebenwirkungen der antiinfektiösen Therapie: Agranulozytose durch β-Laktam-Antibiotika, Vancomycin und Amodiaquin

Hematological side effects of anti-infective therapy: Agranulocytosis caused by γ-Lactam antibiotics, vancomycin and amodiaquine

  • Nebenwirkungsprofile Bei Antibakteriell Wirksamen Chemotherapeutika
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Zusammenfassung

Nebenwirkungen im allgemeinen, und besonders der antiinfektiösen Therapie, treten oft unvorhergesehen auf, und der kausale Zusammenhang ist selten zwingend dargelegt. Der Umgang mit unerwünschten Wirkungen kann erleichtert werden, wenn es gelingt, eine Subpopulation der behandelten Patienten zu definieren, in der sie gehäuft auftritt. Eine wichtige Rolle spielt dabei die Frage nach einer allfälligen Zeitund Dosisabhängigkeit des Auftretens der Nebenwirkung. An den Beispielen der Agranulozytose unter (i) β-Laktam-Antibiotika, (ii) Vancomycin und (iii) Amodiaquin wird gezeigt, wie das Nebeneinander von epidemiologischen und experimentellen Untersuchungen zum Aufdecken von solchen Zusammenhängen führen kann.

Summary

Side effects in general and in particular to antiinfective therapy are obviously hardly predictable and a causal relationship is seldom firmly established. The handling of untoward reactions may be improved if a subpopulation which can be identified is at particular risk for a given reaction. A clear assessment of dose and time dependency of untoward reactions is important in this context. Agranulocytosis seen with (i) β-Lactam-antibiotics, (ii) vancomycin and (iii) amodiaquine can exemplify how simultaneous investigations of epidemiological and experimental aspects lead to identification of a subpopulation at risk.

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  1. Medizinische Klinik, Zieglerspital, CH-3007, Bern, Switzerland

    G. Eich &  K. A. Neftel

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  1. G. Eich
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  2. K. A. Neftel
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Eich, G., Neftel, K.A. Evaluation hämatologischer Nebenwirkungen der antiinfektiösen Therapie: Agranulozytose durch β-Laktam-Antibiotika, Vancomycin und Amodiaquin. Infection 19 (Suppl 1), S33–S37 (1991). https://doi.org/10.1007/BF01644733

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