Abstract
Family studies inXenopus laevis (2n=36 chromosomes) demonstrate the expression of a single major histocompatibility complex in this species. Mixed leukocyte studies in two families ofXenopus vestitus (2n=72 chromosomes) indicated that this reaction was also under the control of a single genetic region. These studies suggest that, in this polyploid species, the switch from tetrasomic to disomic inheritance has already been accomplished for this locus. In contrast, segregation of mixed leukocyte reaction determinants and patterns of graft rejection in two families ofXenopus ruwenzoriensis (2n=108 chromosomes) were incompatible with the expression of a single major histocompatibility complex, and suggest that polysomic inheritance of this locus is maintained in this species. This interpretation was confirmed by the finding in a sibship of hybrids betweenXenopus ruwenzoriensis andXenopus laevis (2n=54+18) of more than four classes of mixed leukocyte reaction-identical sibs. In laboratory-created triploid animals (trispecies hybrid amongXenopus laevis, Xenopus gilli, andXenopus clivii), mixed leukocyte reaction and grafting experiments demonstrated that the major histocompatibility complex of each constituting species was codominantly expressed.
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Du Pasquier, L., Miggiano, V.C., Kobel, H.R. et al. The genetic control of histocompatibility reactions in natural and laboratory-made polyploid individuals of the clawed toadXenopus . Immunogenetics 5, 129–141 (1977). https://doi.org/10.1007/BF01570469
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DOI: https://doi.org/10.1007/BF01570469