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Dominance of colchicine resistance in hybrid CHO cells

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Somatic Cell Genetics

Abstract

Intraspecific hybrids of colchicine-sensitive with colchicine-resistant (CHR) Chinese hamster ovary cells were constructed, using six different colchicine-resistant clones from two independent series. In each instance, colchicine resistance was expressed in an incompletely dominant manner. Some hybrid clones were examined further for the expression of the pleiotropic CHR phenotype and for the cell surfaceP glycoprotein. These features of the colchicine-resistant phenotype were also expressed coordinately.

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Authors and Affiliations

  1. Department of Medical Biophysics, University of Toronto and The Ontario Cancer Institute, 500 Sherbourne Street, M4X 1K9, Toronto, Ontario, Canada

    V. Ling

  2. Center for Cancer Research and Department of Biology, E17-220, Massachusetts Institute of Technology, 02139, Cambridge, Massachusetts

    R. M. Baker

Authors
  1. V. Ling
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  2. R. M. Baker
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Ling, V., Baker, R.M. Dominance of colchicine resistance in hybrid CHO cells. Somat Cell Mol Genet 4, 193–200 (1978). https://doi.org/10.1007/BF01538984

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  • DOI: https://doi.org/10.1007/BF01538984

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