Pediatric Radiology

, Volume 26, Issue 1, pp 48–50 | Cite as

Cushing's disease due to a giant pituitary adenoma in early infancy: CT and MRI features

  • P. Maeder
  • F. Gudinchet
  • R. Meuli
  • B. Rilliet
  • G. Theintz


We report the case of a 12-month-old girl presenting with diabetes insipidus and Cushing's disease. Brain magnetic resonance imaging (MRI) demonstrated a large tumour arising from the sella turcica, extending up to the foramen of Monro and invading the cavernous sinuses. Surgery was performed to remove the suprasellar part of the tumour, and histology revealed an adrenocorticotrophin (ACTH) secreting pituitary adenoma. This entity is very rare in this age group and the MRI features have not previously been described.


Public Health Magnetic Resonance Imaging Adenoma Pituitary Adenoma Large Tumour 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Miller WL, Townsend JJ, Grumbach MM, Kaplan EL (1979) An infant with Cushing's disease due to an adrenocorticotrophin-producing pituitary adenoma. J Clin Endocrinol Metab 48:1017–1025PubMedGoogle Scholar
  2. 2.
    Levy SR, Wynne CV, Lorentz WB (1982) Cushing's syndrome in infancy secondary to pituitary adenoma. Am J Dis Child 1366:605–607Google Scholar
  3. 3.
    Kollias SS, Barkovich AJ, Edwards MSB (1992) Magnetic resonance analysis of suprasellar tumors of childhood. Pediatr Neurosurg 17:284–303Google Scholar
  4. 4.
    Sung DI (1982) Suprasellar tumors in children. A review of clinical manifestations and managements. Cancer 50:1420–1425PubMedGoogle Scholar
  5. 5.
    Haddad SE, VanGilder JC, Menezes AH (1991) Pediatric pituitary tumors. Neurosurgery 29:509–514PubMedGoogle Scholar
  6. 6.
    Richmond IL, Wilson CB (1978) Pituitary adenomas in childhood and adolescence. J Neurosurg 49:163–168PubMedGoogle Scholar
  7. 7.
    Stegner H, Lüdecke DK, Kadrnka-Lovrencic M, Stahnke N, Willig RP (1985) Cushing's disease due to an unusually large adenoma of the pituitary gland in infancy. Eur J Pediatr 143:221–223PubMedGoogle Scholar
  8. 8.
    Young SC, Zimmerman RA, Nowell MA, Bilaniuk LT, Hackney DB, Grossman RI, Godberg HI (1987) Giant cystic craniopharyngiomas. Neuroradiology 29:468–473PubMedGoogle Scholar
  9. 9.
    Hunt SJ, Johnson PC, Coons SW, Pittman HW (1990) Neonatal intracranial teratomas. Surg Neurol 34:336–342PubMedGoogle Scholar
  10. 10.
    Uken P, Sato Y, Smith W (1986) MR findings of malignant intracranial teratoma in a neonate. Pediatr Radiol 16:504–505PubMedGoogle Scholar
  11. 11.
    Boggan JE, Tyrrell JB, Wilson CB (1983) Transsphenoidal microsurgical management of Cushing's disease. Report of 100 cases. J Neurosurg 59:195–200PubMedGoogle Scholar
  12. 12.
    Buchfelder M, Fahlbusch R (1985) Neurosurgical treatment of Cushing's disease in children and adolescents. Acta Neurochir Suppl (Wien) 35:101–105Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • P. Maeder
    • 1
  • F. Gudinchet
    • 1
  • R. Meuli
    • 1
  • B. Rilliet
    • 2
  • G. Theintz
    • 3
  1. 1.Department of RadiologyCentre Hospitalier Universitaire VaudoisLausanneSwitzerland
  2. 2.Department of NeurosurgeryCentre Hospitalier Universitaire VaudoisLausanneSwitzerland
  3. 3.Department of PaediatricsCentre Hospitalier Universitaire VaudoisLausanneSwitzerland

Personalised recommendations