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Loss of constitutional heterozygosity in human astrocytomas

  • Neuropathological Articles
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Summary

Inactivation of tumour suppressor genes or anti-oncogenes as well as activation of dominant acting oncogenes seem to be important mechanisms in the pathogenesis of gliomas. We compared constitutional and tumoural genotypes at different restriction fragment length polymorphism loci (RFLP) on chromosomes 10 and 17 in 15 unrelated individuals

Loss of heterozygosity (LOH) pointing to chromosomal loss or deletions was detected for at least one chromosme 17 marker in 11 gliomas (astrocytomas grades I–III and glioblastoma multiforme), whereas LOH for chromosome 10 loci was only detected in 3 out of 9 cases of glioblastoma multiforme and was not detected in low grade gliomas. Since LOH for chromosome 10 loci seems to be restricted only to glioblastoma multiforme, it is possible that recessive mutations on chromosome 10 are engaged in tumour progression from astrocytomas to glioblastoma multiforme. As LOH of chromosome 17 markers occurs in astrocytomas as in glioblastoma multiforme, chromosome 17 loci probably are involved in early tumour development.

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Authors and Affiliations

  1. Departments of Neurosurgery, Universitair Ziekenhuis Antwerpen, Belgium

    E. Van de Keift & P. Selosse

  2. Departments of Medical Genetics, Universitair Ziekenhuis Antwerpen, Belgium

    K. De Boulle, P. Willems & B. Van der Auwera

  3. Departments of Neuropathology, Universitair Ziekenhuis Antwerpen, Belgium

    J. -J. Martin

Authors
  1. E. Van de Keift
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  2. K. De Boulle
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  3. P. Willems
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  4. J. -J. Martin
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  5. P. Selosse
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  6. B. Van der Auwera
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Van de Keift, E., De Boulle, K., Willems, P. et al. Loss of constitutional heterozygosity in human astrocytomas. Acta neurochir 117, 172–177 (1992). https://doi.org/10.1007/BF01400616

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