Summary
The SOD-like activity of Cu(III) -complexes with polypeptides poly-L-lysine and poly-L-glutamic acid respectively was investigated. The Cu(II)-polypeptide complexes were first oxidized by K2IrCl6 to give the corresponding Cu(III) -compounds.
The oxidation of Cu(II) and the corresponding Cu(II)/Cu(III) potential was evaluated by cyclic voltammetry (c.v.), UV-Vis and EPR spectroscopic (r.t.) experiments. Spin trapping EPR spectra were also conducted to confirm the formation of the superoxide radical. The SOD-like activity of each Cu(III)-complex was proved using the nitro blue tetrazolium (NBT) method slightly modified.
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Liakopoulou-Kyriakides, M., Hadjispyrou, S. & Zarkadis, A. Cu(III)-Polypeptide complexes exhibiting SOD-like activity. Amino Acids 16, 415–423 (1999). https://doi.org/10.1007/BF01388180
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DOI: https://doi.org/10.1007/BF01388180