Summary
A new method for the preparation of N-methylamino acids and some of their derivatives starting from hexafluoroacetone protected amino acids is described. The new concept results in saving of steps compared to conventional protection/activation techniques. Protection and deprotection proceed without racemization.
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Burger, K., Sehedel, H. & Spengler, J. A new protection/activation strategy for the synthesis of naturally occurring and non-naturalα-N-alkylamino acids. Amino Acids 16, 287–295 (1999). https://doi.org/10.1007/BF01388173
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DOI: https://doi.org/10.1007/BF01388173