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Amino Acids

, Volume 12, Issue 2, pp 179–184 | Cite as

Phenytoin protected mouse cortical cell cultures against neurotoxicity induced by kainate but not by NMDA

  • H. Furue
  • N. Fudamato
  • Y. Ohtubo
  • K. Yoshii
Full Papers

Summary

Phenytoin (PHT) protected cultured mouse cortex neurons against kainate-induced excitotoxicity, but failed to protect against the N-methyl-D-aspartate (NMDA)-induced excitotoxicity. The voltage-clamp experiments showed that PHT significantly blocked kainate-induced currents but did not block NMDA-induced currents in the cultured neurons. These results indicate that PHT protects the cultures by blocking non-NMDA receptors and suggest that PHT has clinical efficacy against neuronal cell death through the excessive stimulation of non-NMDA receptors.

Keywords

Amino acids Excitotoxicity Voltage clamp Diphenylhydantoin DPH PHT LDH 

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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • H. Furue
    • 1
  • N. Fudamato
    • 1
  • Y. Ohtubo
    • 1
  • K. Yoshii
    • 1
  1. 1.Department of Biochemical Engineering and ScienceKyushu Institute of TechnologyIizuka, FukuokaJapan

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