Phenytoin protected mouse cortical cell cultures against neurotoxicity induced by kainate but not by NMDA
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Phenytoin (PHT) protected cultured mouse cortex neurons against kainate-induced excitotoxicity, but failed to protect against the N-methyl-D-aspartate (NMDA)-induced excitotoxicity. The voltage-clamp experiments showed that PHT significantly blocked kainate-induced currents but did not block NMDA-induced currents in the cultured neurons. These results indicate that PHT protects the cultures by blocking non-NMDA receptors and suggest that PHT has clinical efficacy against neuronal cell death through the excessive stimulation of non-NMDA receptors.
KeywordsAmino acids Excitotoxicity Voltage clamp Diphenylhydantoin DPH PHT LDH
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