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Amino Acids

, Volume 13, Issue 2, pp 155–161 | Cite as

A new synthesis of the tripeptide Gly-His-Lys with antimicrobial activity

  • M. Liakopoulou-Kyriakides
  • C. Pachatouridis
  • L. Ekateriuiadou
  • V. P. Papageorgiou
Full Papers

Summary

A new solid phase synthesis of the growth-modulating tripeptide Gly-His-Lys is described. 2-Chlorotrityl chloride resin and 9-fluorenylmethoxycarbonyl-(Fmoc), 4-methyltrityl-(Mtt) protecting groups were used. The synthetic tripeptide was tested for its activity against bacteria, yeast and fungi. The in vitro effect of the tripeptide on DNA, RNA and protein synthesis was studied as well.

Keywords

Amino acids Tripeptide GHK Synthesis Antimicrobial activity 

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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • M. Liakopoulou-Kyriakides
    • 1
  • C. Pachatouridis
    • 1
  • L. Ekateriuiadou
    • 2
  • V. P. Papageorgiou
    • 1
  1. 1.Department of Chemical Engineering, Section of ChemistryAristotle University of ThessalonikiThessalonikiGreece
  2. 2.Faculty of ChemistryAristotle University of ThessalonikiThessalonikiGreece

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