Summary
The glutathione analogue γ-(H-Glu-OH)-
-OH (5), containing the 8-membered disulfide ring-
replacing the native -Cys-Gly fragment, has been synthesized and characterized together with its reduced dithiol form γ-(H-Glu-OH)-Cys-Cys-OH (6).
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Abbreviations
- DBU:
-
1,8-diazabicyclo [5.4.0] undec-7-ene;
- DCCI:
-
N,N′-dicyclohexylcarbodiimide
- NMM:
-
N-methylmorpholine
- THF:
-
tetrahydrofuran; (n-Bu)3P, tri-n-butylphosphine
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Calcagni, A., Lucente, G., Luisi, G. et al. Novel glutathione analogues containing the dithiol and disulfide form of the Cys-Cys dyad. Amino Acids 17, 257–265 (1999). https://doi.org/10.1007/BF01366924
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DOI: https://doi.org/10.1007/BF01366924