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Amino Acids

, Volume 15, Issue 1–2, pp 161–177 | Cite as

Is there a correlation between taurine levels and xenobioticinduced perturbations in protein synthesis?: A study with tetracycline in rats

  • Catherine Waterfield
  • D. S. Asker
  • S. Paten
  • J. A. Timbrell
Full Papers

Summary

Changes in urinary levels of taurine have been reported in rats following treatment with various xenobiotics including those which alter protein synthesis and/or are hepatotoxic. This paper reports on the time course of the urinary elevation of taurine following treatment of rats with tetracycline (50, 150 and 200mg.kg-1). Maximum taurine excretion occurred 8–12h following dosing. Serum albumin and total protein were significantly lower after 24h (200mg.kg-1). The increase in urinary taurine was dose-related and reflected in the raised serum levels of taurine 24h after dosing. Serum and urinary protein and [3H]-leucine incorporation into acid precipitable protein in liver and muscle were reduced by tetracycline (100, 150 and 200mg.kg-1) 10h after dosing. The reduction in protein synthesis was correlated with increased urinary and serum levels of taurine at 10h. The use of taurine as a non-invasive marker of protein synthesis is discussed.

Keywords

Amino acids Taurine Protein synthesis Urinary marker Tetracycline Glutathione 

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Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • Catherine Waterfield
    • 1
  • D. S. Asker
    • 1
  • S. Paten
    • 1
  • J. A. Timbrell
    • 2
  1. 1.Biochemical Toxicology, Pharmacy DepartmentKing's CollegeLondonUK
  2. 2.Department of PharmacyKing's College LondonLondonUnited Kingdom

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