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Amino Acids

, Volume 15, Issue 1–2, pp 143–150 | Cite as

Expression and localization of cysteine dioxygenase mRNA in the liver, lung, and kidney of the rat

  • M. Shimadal
  • T. Koide
  • E. Kuroda
  • N. Tsuboyama
  • Y. Hosokawa
  • M. Watanabe
Full Papers

Summary

The expressions of cysteine dioxygenase (CDO) gene in the liver, lung, skeletal muscle, and kidney were studied byin situ hybridization with a cDNA probe from rat liver CDO under normal conditions. Significant expression of the CDO gene was detected in the liver, lung, and kidney, but not skeletal muscle. In the liver, the signal was confined to the cytoplasm of the hepatocytes. Furthermore, the signal was stronger in the periportal than that in the perivenous areas. In the lung, an intensive signal was found in the bronchiolar epithelium. As to the kidney, an intensive signal was observed in the distal convoluted tubules, while no signal was found in the proximal convultions.

Keywords

Amino acids In situ hybridization Cysteine dioxygenase Liver Lung Kidney Rat 

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Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • M. Shimadal
    • 1
  • T. Koide
    • 1
  • E. Kuroda
    • 1
  • N. Tsuboyama
    • 2
  • Y. Hosokawa
    • 2
  • M. Watanabe
    • 1
  1. 1.Department of AnatomyOsaka Medical CollegeTakatsuki City, OsakaJapan
  2. 2.Division of Maternal and Child Health ScienceNational Institute of Health and NutritionTokyoJapan

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