Amino Acids

, Volume 15, Issue 1–2, pp 89–97 | Cite as

Antidiuretic hormone infusion reduces taurine and NaCl-induced hypernatremia in the rats

  • M. J. McBroom
  • A. Qureshi
  • N. Davidson
Full Papers


Rats drinking taurine and hypertonic saline (T + S) develop severe hypernatremia, but rats drinking either T or S alone do not. One hypothesis for this disruption of homeostasis is that the T + S combination interferes with the actions of antidiuretic hormone (ADH). Rats drinking T + S developed severe hypernatremia (170 mmol/L) by day 8 when infused with distilled water by osmotic minipumps, but maintained plasma sodium below 150 mmol/ L when infused with ADH. Cumulative water balance in T + S drinkers receiving ADH was consistently higher than in those not receiving ADH. However the ratio of cumulative sodium balance to cumulative water balance suggests little uniform advantage to rats receiving ADH nor does comparison of urine osmolality in the two groups. Precisely how ADH administration reduces hypernatremia in T + S drinking rats remains unclear, but the hypothesis that T + S interferes with the action of ADH in its regulation of extracellular fluid volume and osmolality remains viable.


Amino acids Taurine Hypernatremia Antidiuretic hormone Salt and water balance 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Atlas M, Bahl JJ, Roeske W, Bressler R (1984) In vitro osmoregulation of taurine in fetal mouse hearts. J Mol Cell Cardiol 16: 311–320Google Scholar
  2. Carla V, Dacke CG, Davidson N, Giotti A, Magnani M, Sgaragli G (1981) Taurine and thermoregulation: behavioral and cellular studies. Adv Exp Biol Med 139: 361–376Google Scholar
  3. Collu R, Charpenet G, Clermont MJ (1978) Antagonism by taurine of morphine induced growth hormone secretion. Can J Neurol Sci 5: 139–142Google Scholar
  4. de Wardener HE, del Greco F (1955) Influence of solute excretion rate on production of hypotonic urine in man. Clin Sci 14: 715–723Google Scholar
  5. Dlouha H, Krecek J (1986) Hypernatremia in taurine and saline drinking rats - Any link to atrial natriuretic factor? Fed Proc 45: 1023Google Scholar
  6. Fujita T, Sato Y (1988) Hypotensive effect of taurine. Possible involvement of the sympathetic nervous system and endogenous opiates. J Clin Invest 82: 993–997Google Scholar
  7. Fujita T, Sato Y, Ando K (1986) Changes in cardiac and hypothalamic noradrenergic activity with taurine in DOCA-salt rats. Am J Physiol 251 (Heart Circ Physiol): H920–H933Google Scholar
  8. Glantz SA (1992) Primer of biostatistics, 3rd edn. McGraw-Hill, New York, p 440Google Scholar
  9. Hanretta AT, Lombardini JB (1987) Is taurine a hypothalamic neurotransmitter? A model of the differential uptake and compartmentalization of taurine by neural and glial cell particles from the rat hypothalamus. Brain Res Rev 12: 167–201Google Scholar
  10. Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72: 101–163Google Scholar
  11. Mangum C, Towle D (1977) Physiological adaptation to unstable environments. Am Sci 65: 67–75Google Scholar
  12. McBroom MJ, Davidson N (1995) Sodium and water balance in rats drinking taurine and different concentrations of hypertonic saline. FASEB J 9: A631Google Scholar
  13. McBroom MJ, Davidson N (1996)β-Alanine protects against taurine and NaCl-induced hypernatremia in the rat. Proc Soc Exp Biol Med 211: 184–189Google Scholar
  14. McBroom MJ, Davidson N (1997) Antidiuretic hormone (ADH; arginine vasopressin; aVP) administration in taurine and hypertonic saline-induced hypernatremia. Amino Acids 13/1: 82–83Google Scholar
  15. McBroom MJ, Rinaudo MS, Clough DL, Mueller GP, Haddy FJ (1989) Taurine and NaCl: untoward effects and a possible role for the heart. In: Iwata S, Lombardini JB, Segawa T (eds) Taurine and the heart. Kluwer Academic Publishers, Boston, pp 99115Google Scholar
  16. McBroom MJ, Temsah RM, Mathew M (1990) Sodium and water balance in rats drinking taurine and hypertonic saline. FASEB J 4: A521Google Scholar
  17. Price MT, Olney JW, Mitchell MV, Fuller T, Cicero TJ (1978) Luteinizing hormone releasing action of N-methyl aspartate is blocked by GABA or taurine but not by dopamine antagonists. Brain Res 158: 461–465Google Scholar
  18. Scheibe J, Elsasser T, Brown B, Dom R, Ondo JG (1984) The stimulation of prolactin secretion by taurine: studies on the site of action. Brain Res Bull 13: 49–52Google Scholar
  19. Schmidt CLA, von Adelung E, Watson T (1918) On the elimination of taurine administered to man. J Biol Chem 33: 501–503Google Scholar
  20. Singewald N, Guo L, Phillipu A (1993) Taurine release in hypothalamus is altered by blood pressure changes and neuroactive drugs. Eur J Pharmacol 240: 21–27Google Scholar
  21. Trachtman H, Barbour R, Sturman JA, Finberg L (1988) Taurine and osmoregulation: Taurine is a cerebral osmoprotective molecule in chronic hypernatremic dehydration. Pediatr Res 23: 35–39Google Scholar
  22. van Gelder NM (1983) A central mechanism of action for taurine: osmoregulation, bivalent cations and excitation threshold. Neurochem Res 8: 687–699Google Scholar
  23. Wright CE, Tallan HH, Lin YY, Gaull GE (1986) Taurine: biological update. Ann Rev Biochem 55: 427–453Google Scholar

Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • M. J. McBroom
    • 1
  • A. Qureshi
    • 2
  • N. Davidson
    • 2
  1. 1.Department of PhysiologySt. George's University School of MedicineGrenadaWest Indies
  2. 2.Department of Physiology, Faculty of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates

Personalised recommendations