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Changes in urinary taurine and hypotaurine excretion after two-thirds hepatectomy in the rat

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Summary

This study followed the time course of urinary taurine and hypotaurine excretion after two-thirds hepatectomy in rats. The excretion of both taurine and hypotaurine was elevated during 18th following the hepatectomy, with maximal excretion during the first 6h. Twelve and 24h after partial hepatectomy, the hepatic hypotaurine concentration was increased but liver taurine did not differ significantly from controls. No changes were observed in hypotaurine and taurine concentrations of heart, kidney, lung, muscle tissue and spleen. We postulate that partial hepatectomy induces a rapid increase of hepatic (hypo)taurine synthesis from precursor amino acids. The increased (hypo)taurine concentrations spill over into urine.

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Authors and Affiliations

  1. Department of Oral Biochemistry, ACTA, van der Boechorststraat 7, NL-1081, BT Amsterdam, The Netherlands

    Henk S. Brand Ph.D.

  2. J. van Gool Laboratory for Experimental Internal Medicine, AMC, Amsterdam, The Netherlands

    G. G. A. Jörning & R. A. F. M. Chamuleau

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  1. Henk S. Brand Ph.D.
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  2. G. G. A. Jörning
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  3. R. A. F. M. Chamuleau
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Brand, H.S., Jörning, G.G.A. & Chamuleau, R.A.F.M. Changes in urinary taurine and hypotaurine excretion after two-thirds hepatectomy in the rat. Amino Acids 15, 373–383 (1998). https://doi.org/10.1007/BF01320901

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  • DOI: https://doi.org/10.1007/BF01320901

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