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Effect of synthetic prostaglandin E1 analog (ornoprostil) on gastric emptying and pancreatic polypeptide release after solid-meal ingestion in man

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Abstract

The effect of orally administered ornoprostil, 17S,20-dimethyl-6-oxoprostaglandin E1 methyl ester, on gastric emptying and on pancreatic polypeptide (PP) release after solid meal ingestion, was investigated in man. A radionuclide technique was used to measure gastric emptying of eight healthy volunteers. In addition, four parameters [SI (starting index): the lag time in the start of emptying;K value: the emptying rate;T1/2: the half emptying time; 120 min RR: the percent retention at 120 min] were determined for evaluation. Also, the PP response was analyzed according to two parameters: IPPRSI, the integrated PP response for periods up to SI, and IPPR120, the integrated PP response for 120 min. The results demonstrated that 5 μg of orally administered ornoprostil significantly reduced the gastric emptying rate of solid meal (T1/2 and 120 min RR,P<0.05). However, ornoprostil affected neither the basal PP concentrations nor the cephalic phase of PP secretion which was determined as IPPRSI. This thus suggests that ornoprostil affects the gastric motor function without interfering with the vagal-cholinergic pathway to the stomach.

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References

  1. Robert A, Nezamis JE, Phillips JP: Inhibition of gastric secretion by prostaglandins. Am J Dig Dis 12:1073–1076, 1967

    Google Scholar 

  2. Wilson DE, Phillips C, Levine RA: Inhibition of gastric secretion in man by prostaglandin A1. Gastroenterology 61:201–206, 1971

    Google Scholar 

  3. Classen M, Koch H, Bickhardt J, Topf G, Demling L: The effect of prostaglandin E1 on the pentagastrin-stimulated gastric secretion in man. Digestion 4:333–334, 1971

    Google Scholar 

  4. Robert A, Nezamis JE, Lancaster C, Hanchar AJ: Cytoprotection by prostaglandins in rats. Gastroenterology 77:433–443, 1979

    Google Scholar 

  5. Robert A, Lancaster C, Davis JP, Field SO, Wickrema SAJ, Thornburgh BA: Cytoprotection by prostaglandin occurs in spite of penetration of absolute ethanol into the gastric mucosa. Gastroenterology 88:328–333, 1985

    Google Scholar 

  6. Peterson W, Feldman M, Taylor I, Bremer M: The effect of 15(R),15-methyl-prostaglandin E2 on meal-stimulated gastric acid secretion, serum gastrin, and pancreatic polypeptide in duodenal ulcer patients. Dig Dis Sci 24:381–384, 1979

    Google Scholar 

  7. Kawai Y, Saeki S, Okano H, Miyamoto M, Oh T, Takata A, Onoyama Y, Mitooka H, Tomofuji Y, Yasuda T, Baba S: A new preparation of solid meal for gastric emptying measurement. Jpn J Gastroenterol 84:130, 1987

    Google Scholar 

  8. Mizuno N, Ishida M, Okada K, Baba S: Studies on the radioimmunoassay of human pancreatic polypeptide (hPP) and basal levels of plasma hPP in healthy subjects and diabetic patients. J Jpn Diab Soc 22:895–905, 1979

    Google Scholar 

  9. Inui A, Mizuno N, Oya M, Suenaga K, Morioka H, Ogawa T, Ishida M, Baba S: Cross-reactivities of neuropetide Y and peptide YY with pancreatic polypeptide antisera; evidence for the existence of pancreatic polypeptide in the brain. Brain Res 330:386–389, 1985

    Google Scholar 

  10. Ruwart MJ, Rush BD: Prostacyclin inhibits gastric emptying and small-intestinal transit in rats and dogs. Gastroenterology 87:392–395, 1984

    Google Scholar 

  11. Nompleggi D, Myers L, Castell DO, Dubois A: Effect of a prostaglandin E2 analog on gastric emptying and secretion in rhesus monkeys. J Pharmacol Exp Ther 212:491–495, 1980

    Google Scholar 

  12. Shea-Donohue PT, Nompleggi D, Dubois A: Effect of a prostaglandin F2α analog on gastric emptying and secretion in rhesus monkeys. J Pharmacol Exp Ther 219:287–289, 1981

    Google Scholar 

  13. Nylander B, Mattsson O: Effect of 16,16-dimethyl prostaglandin E2 on gastric emptying and intestinal transit of barium-food test meal in man. Scand J Gastroenterol 10:289–292, 1975

    Google Scholar 

  14. Robert A, Nezamis JE, Lancaster C: The effect of 16,16-dimethyl prostaglandin E2 on gastric emptying.In Advances in Prostaglandin and Thromboxane Research. B Samuelsson (eds). New York, Raven Press, 1976, pp 507–520

    Google Scholar 

  15. Gilbert DA, Surawicz CM, Silverstein FE, Weinberg CR, Saunders DR, Feld AD, Sanford RL, Bergman D, Washington P: Prevention of acute aspirin-induced gastric mucosal injury by 15-R-15 methyl prostaglandin E2: An endoscopic study. Gastroenterology 86:339–345, 1984

    Google Scholar 

  16. Moore JG, Alazraki N, Clay GD: Effect of synthetic prostaglandin E1 analog on gastric emptying of meals in man. Dig Dis Sci 31:16–20, 1986

    Google Scholar 

  17. Milenov K, Golenhofen K: Contractile responses of longitudinal and circular smooth muscle of the canine stomach to prostaglandins E and F2α. Prostaglandins Leukotriens Med 8:287–300, 1982

    Google Scholar 

  18. Andersson KE, Andersson R, Hedner P, Persson CGA: Parallelism between mechanical and metabolic responses to cholecystokinin and prostaglandin E2 in extrahepatic biliary tract. Acta Physiol Scand 89:571–579, 1973

    Google Scholar 

  19. Thornell E, Svanvik J, Wood JR: Effects of intraarterial prostaglandin E2 on gallbladder fluid transport, motility, and hepatic bile flow in the cat. Scand J Gastroenterol 16:1083–1088, 1981

    Google Scholar 

  20. Jivegård L, Svanvik J: The influence of morphine, loperamide and naloxone on gallbladder response to prostaglandin E2 in the anaesthetized cat. Cata Physiol Scand 127:275–279, 1986

    Google Scholar 

  21. Nakata K, Kurahashi K: Effect of C-terminal octapeptide of cholecystokinin and prostaglandins on adrenergic functions in the guinea-pig gallbladder and sphincter of Oddi. Jpn J Pharmacol 31:77–83, 1981

    Google Scholar 

  22. Sakaki H: Pharmacological studies on terminal biliary duct with particular reference to effects of prostaglandins and a few other drugs. Jpn J Smooth Muscle Res 11:95–107, 1975

    Google Scholar 

  23. Jivegård L, Thornell E, Svanvik J: Intraluminal prostaglandin E2 by activation of nerves reduces fluid absorption and contracts the gallbladder. Gastroenterology 88:1668, 1985

    Google Scholar 

  24. Okano H, Saeki S, Nakashima T, Miyamoto M, Oh T, Takata A, Kawai Y, Onoyama Y, Mitooka H, Tomofuji Y, Yasuda T, Inui A, Baba S: The derangement of gastric, gallbladder emptying and human pancreatic polypeptide release after a test meal ingestion in patients with anorexia nervosa. Gastroenterology 96:A376, 1989

    Google Scholar 

  25. Schwartz TW: Pancreatic polypeptide: a hormone under vagal control. Gastroenterology 85:1411–1425, 1983

    Google Scholar 

  26. Schwartz TW, Stenquist B, Olbe L, Stadil F: Synchronous oscillations in the basal secretion of pancreatic polypeptide and gastric acid. Depression by cholinergic blockade of pancreatic-polypeptide concentrations in plasma. Gastroenterology 76:14–19, 1979

    Google Scholar 

  27. Inui A, Mizuno N, Ogawa T, Ishida M, Baba S: The effects of the physical state of food on postprandial pancreatic polypeptide release in canine. Biomed Res 4(suppl):245–250, 1983

    Google Scholar 

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Authors and Affiliations

  1. Second Department of Internal Medicine, Kobe University School of Medicine, Kusunoki-cho, Chuo-ku, 650, Kobe, Japan

    Hiroyuki Okano,  Susumu Saeki, Akio Inui, Yukio Kawai, Shinsuke Morimoto, Akiyoshi Ohmoto, Takatoshi Nakashima, Masaki Miyamoto, Toumei Oh, Akihiko Takata, Hideki Mitooka, Yoshinobu Tomofuji, Tsutomu Yasuda, Shigeaki Baba & Masato Kasuga

  2. Hyogo Institute for Research in Adult Diseases, Akashi, Japan

    Hiroyuki Okano,  Susumu Saeki, Akio Inui, Yukio Kawai, Shinsuke Morimoto, Akiyoshi Ohmoto, Takatoshi Nakashima, Masaki Miyamoto, Toumei Oh, Akihiko Takata, Hideki Mitooka, Yoshinobu Tomofuji, Tsutomu Yasuda, Shigeaki Baba & Masato Kasuga

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  1. Hiroyuki Okano
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  2. Susumu Saeki
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  3. Akio Inui
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  4. Yukio Kawai
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  5. Shinsuke Morimoto
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  6. Akiyoshi Ohmoto
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  7. Takatoshi Nakashima
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  8. Masaki Miyamoto
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  9. Toumei Oh
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  10. Akihiko Takata
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  11. Hideki Mitooka
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  12. Yoshinobu Tomofuji
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  13. Tsutomu Yasuda
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  14. Shigeaki Baba
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Okano, H., Saeki, S., Inui, A. et al. Effect of synthetic prostaglandin E1 analog (ornoprostil) on gastric emptying and pancreatic polypeptide release after solid-meal ingestion in man. Digest Dis Sci 36, 47–51 (1991). https://doi.org/10.1007/BF01300086

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  • DOI: https://doi.org/10.1007/BF01300086

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