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Menogaril in the treatment of relapsed multiple myeloma

A phase II trial of the Cancer Center of Wake Forest University

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Summary

Fifteen patients with relapsed multiple myeloma (MM) were treated with menogaril 160 mg/m2 intravenously (IV) every 28 days. No responses were seen: 8 patients had stable disease, 4 progressed after one course of therapy, and 3 patients were removed from study after 1 course for other reasons. Four of the 8 patients with stable disease had an improved performance status, and 3 had a decrease in analgesic use. The major toxicity was myelosuppression. The median progression-free interval was 3.0 months with a range of 0.7 to 22 months and median survival was 11.3 months with a range of 0.7 to 39+ months. Menogaril displays little activity in patients with previously treated MM.

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Authors and Affiliations

  1. Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC, USA

    Julia M. Cruz, Howell B. Dalton, Frederick Richards II, Don V. Jackson, Hyman B. Muss, Patricia J. Zekan & R. L. Capizzi

  2. Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC, USA

    L. Douglas Case

  3. Piedmont Oncology Association, USA

    R. C. Brown, Mark A. O'Rourke & Sreenivas M. Reddy

  4. Southeast Cancer Control Consortium, USA

    William L. Ramseur, Richard A. Brodkin, William B. Herring & John A. Lusk

Authors
  1. Julia M. Cruz
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  2. L. Douglas Case
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  3. Howell B. Dalton
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  4. William L. Ramseur
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  5. Frederick Richards II
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  6. Don V. Jackson
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  7. Hyman B. Muss
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  8. Patricia J. Zekan
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  9. Richard A. Brodkin
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  10. R. C. Brown
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  11. William B. Herring
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  12. John A. Lusk
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  13. Mark A. O'Rourke
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  14. Sreenivas M. Reddy
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  15. R. L. Capizzi
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Cruz, J.M., Case, L.D., Dalton, H.B. et al. Menogaril in the treatment of relapsed multiple myeloma. Invest New Drugs 10, 35–37 (1992). https://doi.org/10.1007/BF01275478

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  • DOI: https://doi.org/10.1007/BF01275478

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