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Integration of measles virus nucleic acid into the cell genome

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Summary

A system of chick embryo fibroblasts chronically infected with measles virus has been obtained, which supported production of the infectious virus in low titres. Virus-specific ribonucleoprotein (200S, 1.31 g/ml) is synthesized in this system and no mature virions can be detected. Hybridization experiments showed that measles virus DNA-transcript is integrated into the cell genome. This may be due to the presence of a latent oncornavirus in chick embryo fibroblasts. Possible relation of the model studied to subacute sclerosing panencephalitis is discussed.

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  1. V. M. Zhdanov

    Present address: D. I. Ivanovsky Institute of Virology, Moscow, USSR

Authors and Affiliations

  1. D. I. Ivanovsky Institute of Virology, Moscow, USSR

    M. I. Parfanovich

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  1. V. M. Zhdanov
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  2. M. I. Parfanovich
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Zhdanov, V.M., Parfanovich, M.I. Integration of measles virus nucleic acid into the cell genome. Archiv f Virusforschung 45, 225–234 (1974). https://doi.org/10.1007/BF01249685

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  • DOI: https://doi.org/10.1007/BF01249685

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