Age limitation in human reproduction: Is it justified?

  • Abraham Benshushan
  • Joseph G. Schenker
News and Views Reproductive Health Care Policies around the World


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  1. 1.
    Eaton JW, Mayaux MJ: The social biology of very high fertility among the Hutterites: The demography of a unique population. Hum Biol 1953;25:206–211Google Scholar
  2. 2.
    Check JH, Nowroozi K, Barnea ER, Shaw KJ, Sauer MV: Successful delivery after age 50: A report of two cases as a result of oocyte donation. Obstet Gynecol 1993;81:835–836Google Scholar
  3. 3.
    Sauer MV, Paulson RJ, Lobo RA: Pregnancy after age 50: Application of oocyte donation to women after natural menopause. Lancet 1993;6:321–323Google Scholar
  4. 4.
    Hollander D, Breen JL: Pregnancy in the older gravida: How old is old? Obstet Gynecol Surv 1990;45:106–112Google Scholar
  5. 5.
    Holloways S, Brock DJ: Changes in maternal age distribution and their possible impact on demand for prenatal diagnostic services. Br Med J Clin Res Ed 1988;296:978–981Google Scholar
  6. 6.
    Gabbe SG, Niebyl JR, Simpson JL (eds): Obstetrics, Normal & Problem Pregnancies, 2nd ed. New York, Churchill Livingstone, 1991Google Scholar
  7. 7.
    Creasy RJ, Resnik R: Maternal Fetal Medicine Principles and Practice, 2nd ed. Philadelphia, W. B. Saunders, 1989Google Scholar
  8. 8.
    Schenker JG: Ovum donation: Ethical and legal aspects. J Assist Reprod Genet 1992;9:411–418Google Scholar
  9. 9.
    Bar-Hava I, Homburg R: The elderly gravida. Isr J Obstet Gynecol 1991;2:184–190Google Scholar
  10. 10.
    Milner M, Barry-Kinsella C, Unwin A, Harrison RF: The impact of maternal age on pregnancy and its outcome. Int J Gynaecol Obstet 1992;38:281–286Google Scholar
  11. 11.
    Jonas O, Chan A, Roder D, Macharper T: Pregnancy outcome in primigravid women aged 35 years and over in South Australia 1986–1988. Med J Aust 1991;154:246–249Google Scholar
  12. 12.
    Berkowitz GS, Skovron ML, Lapinski RH, Berkowitz RL: Delayed childbearing and the outcome of pregnancy. N Engl J Med 1990;322:659–664Google Scholar
  13. 13.
    Friede A, Baldwin W, Rhodes PH, Buehler JW, Strauss LT: Older maternal age and infant mortality in the United States. Obstet Gynecol 1988;72:152–157Google Scholar
  14. 14.
    Seidman DS, Samueloff A, Mor-Yosef S, Schenker JG: The effect of maternal age and socioeconomical background on neonatal outcome. Int J Gynecol Obstet 1990;33:7–12Google Scholar
  15. 15.
    Ales KL, Druzin ML, Santini DL: Impact of advanced maternal age on the outcome of pregnancy. Surg Gynecol Obstet 1990;171:209–216Google Scholar
  16. 16.
    Spellacy WN, Miller SJ, Winegar A: Pregnancy after 40 years of age. Obstet Gynecol 1986;68:452–454Google Scholar
  17. 17.
    Brassil MJ, Turner MJ, Egan DM, MacDonald DW: Obstetric outcome in first-time mothers aged 40 years and over. Eur J Obstet Reprod Biol 1987;25:115–120Google Scholar
  18. 18.
    Cario GM, Fray RE, Morris NF: The obstetric performance of the elderly primigravida. J Obstet Gynaecol 1985;5:237–240Google Scholar
  19. 19.
    Newcomb WW, Rodriguez M, Johnson JW: Reproduction in the older gravida. A literature review. J Reprod Med 1991;36:839–845Google Scholar
  20. 20.
    Benshushan A, Schenker JG: Ovum donation—an overview. J Assist Reprod Genet 1993;10:105–111Google Scholar
  21. 21.
    Schenker JG: The therapeutic approach to infertility in cases of ovarian failure. Ann NY Acad Sci 1991;621:414–430Google Scholar
  22. 22.
    Navot D, Bergh PA, Williams MA, Garrisi GJ, Guzman I, Sandler B, Grunfeld L: Poor oocyte quality rather than implantation failure as a cause of age-related decline in female fertility. Lancet 1991;337(8754):1375–1377Google Scholar
  23. 23.
    Navot D, Bergh PA, Williams M, Garrisi GJ, Guzman I, Sandler B, Fox J, Schreiner Engel P, Hofmann GE, Grunfeld L: An insight into early reproductive processes through the in vivo model of ovum donation. J Clin Endocrinol Metab 1991;72(2):408–414Google Scholar
  24. 24.
    Serhal PF, Craft IL: Oocyte donation in 61 patients. Lancet 1989;1:1185–1187Google Scholar
  25. 25.
    Serhal PF, Craft IL: Ovum donation—a simplified approach. Fertil Steril 1987;48(2):265–269Google Scholar
  26. 26.
    Sauer MV, Paulson RJ, Lobo RA: A preliminary report on oocyte donation extending reproductive potential to women over 40. N Engl J Med 1990;323:1157–1160Google Scholar
  27. 27.
    Levran D, Ben Shlomo I, Dor J, Ben Rafael Z, Nebel L, Mashiach S: Aging of endometrium and oocytes: Observations on conception and abortion rates in an egg donation model. Fertil Steril 1991;56(6):1091–1094Google Scholar
  28. 28.
    Gostwamy RK, Williams G, Steptoe PC: Decreased uterine perfusion: A cause of infertility. Hum Reprod 1988;3:955–959Google Scholar
  29. 29.
    Gosden RG: Maternal age: A major factor affecting the prospects and outcome of pregnancy. Ann NY Acad Sci 1985;442:45–57Google Scholar
  30. 30.
    Abdalla HI, Baber R, Kirkland A, Leonard T, Power M, Studd JW: A report on a 100 cycles of oocyte donation; Factors affecting the outcome. Hum Reprod 1990;5:1018–1022Google Scholar
  31. 31.
    Schwartz D, Mayaux NJ: Female fecundity as a function of age. N Engl J Med 1982;307:404–407Google Scholar
  32. 32.
    Harrison KL, Breen TM, Hennessey JF, Hynes MJ, Keeping JD, Kilvert GT, DeAmbrosis PJ, Molloy D: Patient age and success in a human IVF programme. Aust NZ J Obstet Gynecol 1989;29:326–328Google Scholar
  33. 33.
    Padilla SL, Garcia JE: Effect of maternal age and number of in vitro fertilization procedures on pregnancy outcome. Fertil Steril 1989;52:270–273Google Scholar
  34. 34.
    Ezra Y, Schenker JG: Appraisal of in vitro fertilization. Eur J Obstet Gynecol Reprod Biol 1993;48:127–133Google Scholar
  35. 35.
    Balasch J, Fabregues F, Jove IC, Carmona F, Vanrell JA: Infertility factors and pregnancy outcome in women above age 35. Gynecol Endocrinol 1992;6:31–35Google Scholar
  36. 36.
    Queenan JT, Freeman RK, Niebyl JR, Resnik R, Simpson JL: Managing pregnancy in patients over 35: symposium. Contemp OB/GYN 1987;May:180–198Google Scholar
  37. 37.
    Hansen JP: Older maternal age and pregnancy outcome: A review of the literature. Obstet Gynecol Surv 1986;41:726–742Google Scholar
  38. 38.
    Dorfman SF: Age as a factor in pregnancy. Contemp OB/GYN 1986;Feb:64–77Google Scholar
  39. 39.
    MacLeod J, Gold RZ: The male factor in fertility and infertility. VII. Semen quality in relation to age and sexual activity. Fertil Steril 1953;4:194–207Google Scholar
  40. 40.
    Naftoli A, Riondino G, Brancati A: Studio della funzione gonadale ormonica e spermatogenetica nel corso della senscenza maschile G Gerontol 1972;20:1103–1119Google Scholar
  41. 41.
    Sauer MV, Paulson RJ: Understanding the current status of oocyte donation in the United States: What's really going on out there? Fertil Steril 1992;58:16–18Google Scholar
  42. 42.
    Cunningham FG, MacDonald PC, Gant NF: Williams Obstetrics, 18th ed. Norwalk, CT/San Mateo, CA, Appelton and Lange, 1989Google Scholar
  43. 43.
    Kohn RR: Principles of Mammalian Aging, 2nd ed. Englewood Cliffs, NJ, Prentice-Hall, 1978Google Scholar
  44. 44.
    Jequier AM, Winterton WR: Diagnostic problems of trophoblast disease in women age 50 or more. Obstet Gynecol 1975;423:378–381Google Scholar
  45. 45.
    Johnson HA: Relations between normal aging and disease. Aging 1985;28:1–43Google Scholar
  46. 46.
    Fonteyn VJ, Isada NB: Nongenetic implications of childbearing after age thirty-five. Obstet Gynecol Surv 1988;43:709–720Google Scholar
  47. 47.
    Kaunitz AM, Hughes JM, Grimes DA, Smith JC, Rochat RW, Kafrissen ME: Causes of maternal mortality in the United States. Obstet Gynecol 1985;65:605–611Google Scholar
  48. 48.
    Yasin SY, Beydoun SN: Pregnancy outcome at greater than or equal to 20 weeks' gestation in women in their 40s. A case control study. J Reprod Med 1988;33:209–213Google Scholar
  49. 49.
    Samueloff A, Mor-Yosef S, Seidman DS, Rabinowitz R, Simon A, Schenker JG: Grand multiparity—a nationwide survey. Isr J Med Sci 1989;25:625–629Google Scholar
  50. 50.
    Grimes DA, Gross GK: Pregnancy outcome in black women aged 35 and older. Obstet Gynecol 1981;58:614–620Google Scholar
  51. 51.
    Kujanusuu E, Kivinen S, Tuimala R: Pregnancy and delivery at the age of forty and over. Int J Gynaecol Obstet 1981;19:341–345Google Scholar
  52. 52.
    Tuck SM, Yudkin PL, Turnbull AC: Pregnancy outcome in elderly primigravida with and without a history of infertility. Br J Obstet Gynaecol 1988;95:230–237Google Scholar
  53. 53.
    Kirz DS, Dorchester W, Freeman RK: Advanced maternal age: The mature gravida. Am J Obstet Gynecol 1985;152:7–12Google Scholar
  54. 54.
    Chervenak JL, Kardon NB: Advancing maternal age: The actual risks. The Female Patient 1991;16:17–24Google Scholar
  55. 55.
    Gorodeski IG, Bahari CM: The effect of placenta previa localization upon maternal and fetal neonatal outcome. J Perinat Med 1987;15:169–177Google Scholar
  56. 56.
    Naeye RL: Maternal age, obstetric complications, and the outcome of pregnancy. Obstet Gynecol 1983;61:210–216Google Scholar
  57. 57.
    Messinis I, Malamitsi-Puchner A, Hadijigeorgiou E, Lolis D, Nicolopoulos D: Perinatal complications in elderly primigravidas. Pediatr Padol 1982;17:597–602Google Scholar
  58. 58.
    Blickstein I, Lancet M, Kessler I: Reevaluation of the obstetrical risk for the older primipara. Int J Gynaecol Obstet 1987;25:107–112Google Scholar
  59. 59.
    Halfar MM: Frequency of labor dysfunction in nulliparas over the age of thirty. J Nurse Midwif 1985;30:333–335Google Scholar
  60. 60.
    Haines CJ, Rogers MS, Leung DH: Neonatal outcome and its relationship with maternal age. Aust NZ J Obstet Gynecol 1991;31:209–212Google Scholar
  61. 61.
    Signorelli C, Elliott P, Cattaruzza MS, Osborn J: Trend of cesarean section in Italy: An examination of national data 1980–1985. Int J Epidemiol 1991;20:712–716Google Scholar
  62. 62.
    Narayan H, Buckett W, McDougall W, Cullimore J: Pregnancy after fifty: profile and pregnancy outcome in series of elderly multigravidae. Eur J Obstet Gynecol Reprod Biol 1992;23:47–51Google Scholar
  63. 63.
    Peipert JF, Bracken MB: Maternal age: An independent risk factor for cesarean delivery. Obstet Gynecol 1993;81:200–205Google Scholar
  64. 64.
    Shapiro H, Lyons E: Late maternal age and postdate pregnancy. Am J Obstet Gynecol 1989;160:909–912Google Scholar
  65. 65.
    Dorfman SF: Maternal mortality in New York City, 1981–1983. Obstet Gynecol 1990;76:317–323Google Scholar
  66. 66.
    Cnattingius S, Forman MR, Berendes HW, Isolato L: Delayed childbearing and risk of adverse perinatal outcome. JAMA 1992;268:886–890Google Scholar
  67. 67.
    Forman MR, Meirik O, Berendes HW: Delayed childbearing in Sweden. JAMA 1984;252:3135–3139Google Scholar
  68. 68.
    Kiely JL, Paneth N, Susser M: An assessment of the effects of maternal age and parity in different components of perinatal mortality. Am J Epidemiol 1986;123:444–454Google Scholar
  69. 69.
    Turner MJ, MacDonald D: Pregnancy after the age of 40 years: are the risks increased? J Obstet Gynaecol 1984;5:1–5Google Scholar
  70. 70.
    Davidson EC Jr, Fukushima T: The age extremes for reproduction: Current implications for policy change. Am J Obstet Gynecol 1985;152:467–473Google Scholar
  71. 71.
    Adams PF, Collins G. Measurements of health among older persons living in the community.In Health Statistics on Older Persons, United States, 1986, Haulik RJ, Liu MG, Kovar MG,et al. Vital and Health Statistics, Series 3, No. 25 DHHS Publ No (PHS) 87-1409. Washington, DC, US Government Printing Office, June 1987Google Scholar

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Abraham Benshushan
    • 1
  • Joseph G. Schenker
    • 1
  1. 1.Department of Obstetrics and GynecologyHadassah University Hospital Ein-KeremJerusalemIsrael

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