Abstract
Interleukin-6 (IL-6) levels have been shown to correlate well with the magnitude of surgical stress. Serum IL-6 and plasma granulocytic elastase levels, 24 h after surgery, were determined in 12 patients who underwent open major surgery [MS group; esophageal carcinoma (n=5), gastric carcinoma (n=3), colorectal carcinoma (n=4) 5 patients who had open cholecystectomy [OC group] and 17 patients who had laparoscopic cholecystectomy [LC group]. IL-6 levels correlated significantly with the duration of surgery (r=0.685,P < 0.01) and with intraoperative blood loss (r=0.583,P < 0.02). However, there was no significant correlation between granulocytic elastase and the duration of surgery or blood loss. Plasma IL-6 levels in the LC group (21±3 pg/ml) were significantly lower than those in the OC group (47±5 pg/ml) and the MS group (186±36pg/ml) (P<0.05;P<0.01). However, there was no significant difference in granulocytic elastase levels between the LC group (318±8μg/l), the OC group (360±130 gmg/ml), and the MS group (701±344 μg/l). Increased IL-6 levels correlated well with increased duration of surgery. The lower IL-6 levels following laparoscopic cholecystectomy may therefore be indicative of lower surgical stress associated with laparoscopic cholecystectomy.
Similar content being viewed by others
References
The Southern Surgeon's Club (1991) A prospective analysis of 1518 laparoscopic cholecystectomies. N Engl J Med 324:1073–1078
Reddick EJ, Olsen DO (1989) Laparoscopic laser cholecystectomy: A comparison with mini-lap cholecystectomy. Surg Endosc 3:131–133
DuBois F, Icard P, Berthelot G, Levard H (1990) Coelioscopic cholecystectomy: Preliminary report of 36 cases. Ann Surg 211:60–62
Neugebauer E, Troidl H, Spangenberger W, Dietrich A, Lefering R, and The Cholecystectomy Study Group (1991) Conventional versus laparoscopic cholecystectomy and the randomized controlled trial. Br J Surg 78:150–154
Neumann S, Hennrich N, Gunzer G, Lang H (1981) Enzymelinked immunoassay for elastase from leukocytes in human plasma. J Clin Biochem 19:232–41
Neumann S, Hennrich N, Gunzer G, Lang H (1984) Enzymelinked immunoassay for human granulocytic elastase in complex with alproteinase inhibitor. In: Horl WH, Heidland A (eds) Proteases. Plenum, pp 379–390
Nijsten MWN, De Groot ER, Ten Duis HJ, Klasen HJ, Hack CE, Aarden LA (1987) Serum levels of interleukin-6 and acute phase responses. Lancet II:921
Shenkin A, Fraser WD, Series J, Winstanley FP, McCartney AC, Burns HJG, Van Damme J (1989) The serum interleukin 6 response to elective surgery. Lymphokine Res 8:123–127
Pullicino EA, Carli F, Poole S, Rafferty B, Malik STA, Elia M (1990) The relationship between the circulating concentrations of interleukin 6 (IL-6), tumor necrosis factor (TNF), and the acute phase response to elective surgery and accidental injury. Lymphokine Res 9:231–238
Cruickshank AM, Fraser AM, Burns HJG, van Damme J, Shenkin A (1990) Response of serum interleukin-6 in patients undergoing elective surgery of varying severity. Clin Sci 79:161–165
Baigrie RI, Lamont PM, Kwiatkowski D, Dallman MJ, Morris PJ (1992) Systemic cytokine response after major surgery. Br J Surg 79:757–760
Ohzato H, Yoshizaki K, Nishimoto N, Ogata A, Tagoh H, Monden M, Gotoh M, Kishimoto T, Mori T (1992) Interleukin-6 as a new indicator of inflammatory status: Detection of serum levels of interleukin-6 and C-reactive protein after surgery. Surgery 111:201–209
Joris J, Cigarini I, Legrand M, Jacquest N, De Groote D, Franchimont P, Lamy M (1992) Metabolic and respiratory changes after cholecystectomy performed via laparotomy or laparoscopy. Br J Anaesth 69:341–345
Duswald KH, Jochum M, Schramm W, Fritz H (1985) Released granulocytic elastase: An indicator of pathobiochemical alterations in septicemia after abdominal surgery. Surgery 98:892–899
Author information
Authors and Affiliations
About this article
Cite this article
Oka, M., Hazama, S., Hiwaki, K. et al. Interleukin-6 and granulocytic elastase levels following laparoscopic cholecystectomy. J Hep Bil Pancr Surg 1, 569–572 (1994). https://doi.org/10.1007/BF01211922
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01211922