Background
The population exposed to repeated cycles of gonadotropin-releasing hormone analogue treatment before in vitro fertilization is growing rapidly. Sex steroids have been shown to induce changes in carbohydrate metabolism. In view of the effect of gonadotropinreleasing hormone analogues on sex steroid levels, it seems of interest to investigate carbohydrate metabolism following treatment with these compounds.
Purpose
Our purpose was to assess possible changes in glucose tolerance following administration of the longacting gonadotropin-releasing hormone and analogue,d-Trp6 LH-RH.
Design
A 3-hr oral glucose tolerance test with 100 g glucose was performed on all patients, before and after 6 weeks of treatment.
Results
No significant changes in either glucose tolerance or insulin levels following treatment withD-Trp6 LH-RH were demonstrated in the group of 25 women investigated.
Conclusion
With respect to carbohydrate metabolism,d-Trp6 LH-RH may safely be administered to healthy women. Further studies are still required to assess the safety of this GnRH analogue when treating potentially diabetic and diabetic patients.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Andreyko IL, Marshall LA, Dumesic DA, Jaffe RB: Therapeutic uses of gonadotropin-releasing hormone analogs. Obstet Gynecol Survey 1987;42:1–21
Hammond MP, Wentz AN, Cherrington AD: Alterations in carbohydrate metabolism as they apply to reproductive endocrinology. Fertil Steril 1988;50:387–397
Stout RW: Insulin and atheroma—an update. Lancet 1987;1:1077–1079
Pyorala K, Savolainen E, Kaukola S, Haapakoski J: Plasma insulin as coronary heart disease risk factor and predictive value during 9 + year follow-up of the Helsinki Policemen Study population. Acta Med Scand Suppl 1985;701:38–52
Zavaroni I, Bonora E, Pagliara M,et al. Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med 1989;320:702–706
Keys A, Sidanza F, Karvonen MJ, Kimura N, Taylor HL: Indices of relative weight and obesity. J Chron Dis 1972;25:329–343
Yelow RS, Bauman WA: Plasma insulin in health and disease.In Diabetes Mellitus. Theory and Practice, 3rd ed., M Ellenberg, H Rifkin (eds). Medical Examination 1983, pp 119–125
Godsland IF, Crook D, Simpson R,et al. The effects of different formulations of oral contraceptive agents on lipid and carbohydrate metabolism. N Engl J Med 1990;323:1375–1381
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goldman, G.A., Tadir, Y., Ovadia, J. et al. The impact ofd-Trp6 luteinizing hormone-releasing hormone (LH-RH) on carbohydrate metabolism. J Assist Reprod Genet 10, 78–81 (1993). https://doi.org/10.1007/BF01204445
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01204445