Protein composition of follicular fluid and oocyte cleavage occurrence in in vitro fertilization (IVF)

  • J. Gonzalès
  • S. Lesourd
  • P. Van Dreden
  • P. Richard
  • G. Lefèbvre
  • D. Vauthier Brouzes
Clinical Assisted Reproduction


The present study was carried out from in vitro fertilization (IVF) attempts to analyze further the total and specific protein contents of 47 follicular fluids yielding one oocyte. The aim was to find correlations between the follicular concentrations of such proteins and the occurrence of coupled oocyte cleavage. These findings would be used as markers of IVF outcome. Two groups of follicular samples were distinguished: one group with cleavage occurrence (25 cases) and another group without cleavage or even fertilization (22 cases). In the group with cleavage a significantly higher level was observed for six proteins: C3 complement fraction and ceruleoplasmin (P <0.02), α-antitrypsin and transferrin (P <0.01), and α2-macroglobulin and β2-microglobulin (P <0.001). The data are discussed with respect to changes in follicle permeability with advancing maturity.

Key words

follicular fluid follicular proteins in vitro fertilization oocyte 


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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • J. Gonzalès
    • 1
    • 2
  • S. Lesourd
    • 1
  • P. Van Dreden
    • 1
  • P. Richard
    • 1
  • G. Lefèbvre
    • 2
  • D. Vauthier Brouzes
    • 2
  1. 1.Laboratoire de Biologie de la Reproduction et de CytogénétiqueHôpital PitiéParis Cedex 13France
  2. 2.Department of Obstetrics and GynaecologyHôpital PitiéParisFrance

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