Abstract
By thermolysis of equimolar quantities of 1-R-2-oxo-3-carbethoxy-4-hydroxyquinolines and 2-aminothiazole in diphenyl oxide, we have synthesized N-(2-thiazolyl)amides of 1-R-2-oxo-4-hydroxyquinoline-3-carboxylic acids. some of the substances that were obtained have high antiexudative activity (carrageenan edema), higher than the activity of sudoxicam.
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Additional information
For Communication 22, see [1].
Ukrainian Pharmaceutical Academy, Khar'kov 310002. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1397–1399, October, 1994. Original article submitted November 8, 1994.
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Ukrainets, I.V., Gorokhova, O.V., Taran, S.G. et al. 4-Hydroxy-2-quinolones. 23. N-(2-thiazolyl)amides of 1-R-2-oxo-4-hydroxyquinoline-3-carboxylic acids — A new group of potential antiinflammatory agents. Chem Heterocycl Compd 30, 1211–1213 (1994). https://doi.org/10.1007/BF01184887
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DOI: https://doi.org/10.1007/BF01184887