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Synthesis of 6-amino-2-(p-aminophenyl)-4-phenylquinazoline

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A study was carried out on the amination of 6-chloro-2-arylquinazolines. The reaction of p-chlorophenyl- and p-nitrophenyl derivatives gives a mixture of mono- and diamination products with predominance of the monoamino products. The desired diamine was also obtained in the reduction of 6-amino-2-(p-nitrophenyl)-quinazoline.

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Authors
  1. V. F. Sedova
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  2. O. P. Shkurko
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Additional information

Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 547–550, April, 1995. Original article submitted November 24, 1994. Revision submitted March 10, 1995.

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Sedova, V.F., Shkurko, O.P. Synthesis of 6-amino-2-(p-aminophenyl)-4-phenylquinazoline. Chem Heterocycl Compd 31, 481–484 (1995). https://doi.org/10.1007/BF01177022

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