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Condensed isoquinoline. 5. Reaction of the 6-methyl-5-oxoisoquino[2,3-a] Quinazolinium cation with certain nucleophiles

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

It has been shown that nucleophilic reagents react with the 6-methyl-5-oxoisoquino[2,3-a]quinazolinium cation at the C(2) atom. The structure of the reaction product is determined by the type of reagent. On reaction with sodium borohydride and secondary amines, 12H- and 12-dialkylamino-12H-6-methyl-5-oxo-5, 6-dihydroisoquino[2,3-a]quinazolines are formed. In the case of primary amines the reaction is accompanied by fission of the C(12)-N(t3) bond with the formation of 2-[o-(N-alkylformimidoyl)-benzyl]-3-methyl-4-oxoquinazolines.

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References

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Authors
  1. V. M. Kisel'
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  2. V. A. Kovtunenko
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  3. L. M. Potikha
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  4. A. V. Turov
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Additional information

See [1) for the preceding communication.

T. G. Shevchenko Kiev University, Kiev 252017. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 522–526, April, 1995. Original article submitted March 24, 1995.

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Kisel', V.M., Kovtunenko, V.A., Potikha, L.M. et al. Condensed isoquinoline. 5. Reaction of the 6-methyl-5-oxoisoquino[2,3-a] Quinazolinium cation with certain nucleophiles. Chem Heterocycl Compd 31, 457–460 (1995). https://doi.org/10.1007/BF01177018

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  • DOI: https://doi.org/10.1007/BF01177018

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