Abstract
A new method of synthesizing thiophene analogs of chalcones, based on condensing aryl-β-chlorovinyl ketones with thiophene in the presence of stannic chloride, is extended. Hitherto undescribed thiophene analogs of chalcones are obtained in good yields. Addition of 2-nitropropane, nitromethane, and morpholine to the active double bond of thiophene analogs of chalcones gives γ-nitroketones and morpholine derivatives of ketones containing the benzene ring and thiophene. Oxidation with alkaline hydrogen peroxide gives an α-ketooxide of the thiophene analog of chalcone.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
V. F. Belyaev, KhGS [Chemistry of Heterocyclic Compounds], 215, 1965.
V. F. Lavrushin, S. V. Tsukerman, and V. M. Nikitchenko, ZhOKh,31, 2845, 1961;32, 2326, 1962.
Z. N. Nazarova and A. D. Garnovskii, ZhOKh,30, 1182, 1960.
V. F. Lavrushin, S. V. Tsukerman, and V. M. Nikitchenko, Ukr. khim. zh.,27, 379, 1961.
K. Nakanishi, Infrared Spectra and Structure of Organic Compounds [Russian translation], Mir, Moscow, 45, 64, 1965.
N. S. Kozlov and G. N. Kozlov, ZhOKh,33, 2185, 1963.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Belyaev, V.F., Abrazhevich, A.I. Synthesis and reactions of thiophene analogs of chalcones. Chem Heterocycl Compd 3, 170–172 (1967). https://doi.org/10.1007/BF01172540
Issue Date:
DOI: https://doi.org/10.1007/BF01172540